                               SEQUENCE LISTING

<110> WHETSTINE, JOHNATHAN R.
 
<120> METHODS RELATING TO THE PREVENTION AND TREATMENT OF DRUG 
      RESISTANCE

<130> 030258-085091-PCT

<140> PCT/US2016/032043
<141> 2016-05-12

<150> 62/162,141
<151> 2015-05-15

<160> 40    

<170> PatentIn version 3.5

<210> 1
<211> 4526
<212> DNA
<213> Homo sapiens

<400> 1
acggctgcgc agatgccgac tttagaggag gcggagtttc ggccttcgcc tgctggaaaa       60

gcagtaggat cggccagtgg cgacagcagg agctgagcct aagccctggc ggggctttgg      120

gctgtagatt cctgtctgac taaagggacc tcaaaaagga gggaaaatgg cttctgagtc      180

tgaaactctg aatcccagtg ctaggataat gaccttttat ccaactatgg aagagttccg      240

aaacttcagt agatacattg cctacattga atcccaagga gctcatcggg cagggctagc      300

caaggttgtt cctccaaaag agtggaagcc acgagcatcc tatgatgaca ttgatgattt      360

ggtcattcct gcccccattc aacagctggt gacggggcag tctggcctct ttactcagta      420

caacatacag aagaaagcca tgactgttcg agagttccgc aagatagcca atagcgataa      480

gtactgtacc ccacgctata gtgagtttga agagctcgag cggaaatact ggaaaaatct      540

tacattcaat cctccaatct atggtgcaga tgtgaatggt accctctatg aaaagcatgt      600

tgatgagtgg aatattggcc ggctgagaac aatcctggac ttggtggaaa aggagagtgg      660

gatcaccatt gagggtgtga acaccccata cctgtacttt ggcatgtgga agacatcctt      720

tgcttggcac actgaagaca tggacctcta cagcatcaac tacctgcact ttggagaacc      780

aaagtcctgg tactctgttc cacctgagca tggaaagcgg ttggaacgcc tcgccaaagg      840

ctttttccca ggaagtgctc aaagctgtga ggcatttctc cgccacaaga tgaccctgat      900

ttccccgtta atgctgaaga aatatggaat tccctttgac aaggtgactc aagaggctgg      960

agagtttatg atcactttcc cttatggtta ccatgccggc tttaaccatg gttttaactg     1020

tgcggagtct accaattttg ctacccgtcg gtggattgag tacggcaagc aagctgtgct     1080

gtgctcctgt agaaaggaca tggtgaagat ctccatggat gtgtttgtga gaaagttcca     1140

gccagaaagg tacaaacttt ggaaagctgg gaaggacaac acagttattg accatactct     1200

gcccacgcca gaagcagctg agtttcttaa ggagagtgaa ctgcctccaa gagctggcaa     1260

cgaggaggag tgcccagagg aggacatgga aggggtggag gatggagagg aaggagacct     1320

gaagacaagc ctggccaagc accgaatagg gacaaagagg caccgagttt gtcttgaaat     1380

accacaggag gtgagtcaga gtgagctctt ccccaaggag gatctgagtt ctgagcagta     1440

tgagatgacg gagtgcccgg cagccctcgc ccctgtgagg cccacccata gctctgtgcg     1500

gcaagttgag gatggtctta ccttcccaga ttattctgac tccactgaag tcaaatttga     1560

agagcttaaa aatgtcaaac tagaagagga ggatgaggag gaagaacaag cagcagctgc     1620

cttggatctt tctgtgaatc ctgcgtctgt agggggacgc cttgtcttct caggctccaa     1680

aaagaaatca tcttctagcc tgggctctgg ctcttcacgg gattctatct cttctgattc     1740

agaaactagt gagcctctct cctgccgagc ccaagggcaa acgggagttc tcactgtgca     1800

cagttatgcc aaaggggatg gcagggtcac tgtgggagag ccatgcacga ggaagaaagg     1860

aagcgccgct agaagtttca gtgagcggga gctggcagag gttgcagatg aatacatgtt     1920

ttccctagaa gagaataaga agtccaaggg acgccgtcag cctttaagca agctcccccg     1980

ccatcaccca cttgtgctgc aggagtgtgt cagtgatgat gagacatctg aacagctgac     2040

ccctgaggaa gaggctgagg agacagaggc ctgggccaag cctctgagcc aactgtggca     2100

gaaccgacct ccaaactttg aggctgagaa ggaattcaat gagaccatgg cccaacaggc     2160

ccctcactgc gctgtctgta tgatcttcca gacttatcat caggttgaat ttggaggctt     2220

taatcagaac tgtggaaatg cttcagattt agccccccag aagcagagga ccaagccatt     2280

gattccagaa atgtgcttca cttcgactgg ctgcagcacg gacatcaacc tttctactcc     2340

ttatcttgag gaggatggca ccagcatact cgtttcctgc aagaagtgca gcgtccgggt     2400

ccatgccagt tgctatgggg tcccccctgc aaaggcttct gaagactgga tgtgttctcg     2460

gtgttcagcc aatgccctag aggaggactg ctgtttatgc tcattacgag gaggggccct     2520

gcagagagca aatgatgaca ggtgggtcca cgtttcatgt gctgtggcaa ttctggaagc     2580

aaggtttgtc aacattgcag aaagaagtcc ggtggatgtg agcaaaatcc ccctgccccg     2640

cttcaaactg aaatgtatct tctgtaagaa gcggaggaaa agaactgctg gctgctgtgt     2700

gcagtgttct cacggccgct gcccaactgc cttccatgtg agctgcgccc aggctgccgg     2760

tgtgatgatg cagcctgacg actggccttt tgtggtcttc attacctgct ttcggcacaa     2820

gattcctaat ttggagcgtg ccaagggggc cttgcaaagc atcactgcag gccagaaagt     2880

cattagcaag cataagaacg ggcgcttcta ccagtgtgaa gtggtcaggc tcaccaccga     2940

gaccttctat gaagtcaact ttgatgatgg ctccttcagc gacaatcttt atcctgagga     3000

catagtgagc caggactgtc tccagtttgg tcctcctgct gaaggggaag tggtccaagt     3060

gagatggaca gacggccaag tctatggagc caagtttgtg gcctcccacc ctatccaaat     3120

gtaccaggtg gagtttgagg atggctcaca acttgtggtt aagagagatg atgtatacac     3180

actggatgaa gagcttccca agagagtcaa atctagactg tcagtagcct cagacatgcg     3240

cttcaatgag attttcacag agaaagaggt taagcaagaa aagaaacggc aacgagttat     3300

caactcaaga taccgggaag attatattga gcctgcacta taccgggcca tcatggagta     3360

ggtgcttcca gggtccaagg gattctcagc catccaggca agagcactct gggttccaca     3420

gcacagcaga catggaacgc tgaagtctct gaaagtgaag ttgtaaaaag aaaaggaatg     3480

aaataaccga cccatcatct tctcacccac cctcattgca ttccgctgta gtgaaaggac     3540

gagccatttc tgggcacgtg gcagcagtcg ctgatctccc agctgagggg ctgagcactg     3600

gaatgctgtg gctgcactgg ccccagtcca tagaggggtc aactatgctg gctggactgg     3660

ctgccttgtt cctggcctag gacttagctt cataactatc acctgcaccg actaggctga     3720

ggtgctggta cttgccccaa cccctacttt tgtatttata tgtgtgtgtg tgtgtgcgtg     3780

cgtgcgtgcg tgcgtgtatg tttggtctgg accagcttct gccagcccct ggcctttact     3840

ttcttccttg cctatgcagg gcaaacaaaa tgtgaaattc tgccctcagc tgagctgagt     3900

aagggctcct gggggttggc tggagatggg tgtggcatct gtccaggcct ggaaccgtct     3960

caagacagtg ctggcaaagc tgcagtattg agatgctaag gagctgatgc cacctctttg     4020

tcttccccta aaggagaaca tggggataac atgggtgtgt gcccacaaca ctctaggtgc     4080

agagcccctg tggcaaagta ttacagggtg tgggtgggga ttaccctgaa tcggggattt     4140

taatgatgga agcaggcaga gcctggtggg tgattctgtc aacagaaaat tgcaatcatg     4200

caggggctgg gagggttagg atgaaaaaac tggggccatt ggaggcccac tgtaggtggg     4260

agggagctga ttttggggtg gggggtggga ctagagggca atactgaagg ggttaaacag     4320

gtttttgctc ctcaagaatt tgtttgcctg ggcccaggat tggagggctt cacaccaata     4380

ccctgtgtat acaagaatca gatttataat acttcccctt ttttgttacg tatgaacact     4440

ataaaccaaa ttattttgaa aactggtgca tcaccttgtc cttagcaata aaatgtgttg     4500

agcagaggaa aaaaaaaaaa aaaaaa                                          4526


<210> 2
<211> 1064
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Ser Glu Ser Glu Thr Leu Asn Pro Ser Ala Arg Ile Met Thr 
1               5                   10                  15      


Phe Tyr Pro Thr Met Glu Glu Phe Arg Asn Phe Ser Arg Tyr Ile Ala 
            20                  25                  30          


Tyr Ile Glu Ser Gln Gly Ala His Arg Ala Gly Leu Ala Lys Val Val 
        35                  40                  45              


Pro Pro Lys Glu Trp Lys Pro Arg Ala Ser Tyr Asp Asp Ile Asp Asp 
    50                  55                  60                  


Leu Val Ile Pro Ala Pro Ile Gln Gln Leu Val Thr Gly Gln Ser Gly 
65                  70                  75                  80  


Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val Arg Glu 
                85                  90                  95      


Phe Arg Lys Ile Ala Asn Ser Asp Lys Tyr Cys Thr Pro Arg Tyr Ser 
            100                 105                 110         


Glu Phe Glu Glu Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr Phe Asn 
        115                 120                 125             


Pro Pro Ile Tyr Gly Ala Asp Val Asn Gly Thr Leu Tyr Glu Lys His 
    130                 135                 140                 


Val Asp Glu Trp Asn Ile Gly Arg Leu Arg Thr Ile Leu Asp Leu Val 
145                 150                 155                 160 


Glu Lys Glu Ser Gly Ile Thr Ile Glu Gly Val Asn Thr Pro Tyr Leu 
                165                 170                 175     


Tyr Phe Gly Met Trp Lys Thr Ser Phe Ala Trp His Thr Glu Asp Met 
            180                 185                 190         


Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys Ser Trp 
        195                 200                 205             


Tyr Ser Val Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu Ala Lys 
    210                 215                 220                 


Gly Phe Phe Pro Gly Ser Ala Gln Ser Cys Glu Ala Phe Leu Arg His 
225                 230                 235                 240 


Lys Met Thr Leu Ile Ser Pro Leu Met Leu Lys Lys Tyr Gly Ile Pro 
                245                 250                 255     


Phe Asp Lys Val Thr Gln Glu Ala Gly Glu Phe Met Ile Thr Phe Pro 
            260                 265                 270         


Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu Ser 
        275                 280                 285             


Thr Asn Phe Ala Thr Arg Arg Trp Ile Glu Tyr Gly Lys Gln Ala Val 
    290                 295                 300                 


Leu Cys Ser Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp Val Phe 
305                 310                 315                 320 


Val Arg Lys Phe Gln Pro Glu Arg Tyr Lys Leu Trp Lys Ala Gly Lys 
                325                 330                 335     


Asp Asn Thr Val Ile Asp His Thr Leu Pro Thr Pro Glu Ala Ala Glu 
            340                 345                 350         


Phe Leu Lys Glu Ser Glu Leu Pro Pro Arg Ala Gly Asn Glu Glu Glu 
        355                 360                 365             


Cys Pro Glu Glu Asp Met Glu Gly Val Glu Asp Gly Glu Glu Gly Asp 
    370                 375                 380                 


Leu Lys Thr Ser Leu Ala Lys His Arg Ile Gly Thr Lys Arg His Arg 
385                 390                 395                 400 


Val Cys Leu Glu Ile Pro Gln Glu Val Ser Gln Ser Glu Leu Phe Pro 
                405                 410                 415     


Lys Glu Asp Leu Ser Ser Glu Gln Tyr Glu Met Thr Glu Cys Pro Ala 
            420                 425                 430         


Ala Leu Ala Pro Val Arg Pro Thr His Ser Ser Val Arg Gln Val Glu 
        435                 440                 445             


Asp Gly Leu Thr Phe Pro Asp Tyr Ser Asp Ser Thr Glu Val Lys Phe 
    450                 455                 460                 


Glu Glu Leu Lys Asn Val Lys Leu Glu Glu Glu Asp Glu Glu Glu Glu 
465                 470                 475                 480 


Gln Ala Ala Ala Ala Leu Asp Leu Ser Val Asn Pro Ala Ser Val Gly 
                485                 490                 495     


Gly Arg Leu Val Phe Ser Gly Ser Lys Lys Lys Ser Ser Ser Ser Leu 
            500                 505                 510         


Gly Ser Gly Ser Ser Arg Asp Ser Ile Ser Ser Asp Ser Glu Thr Ser 
        515                 520                 525             


Glu Pro Leu Ser Cys Arg Ala Gln Gly Gln Thr Gly Val Leu Thr Val 
    530                 535                 540                 


His Ser Tyr Ala Lys Gly Asp Gly Arg Val Thr Val Gly Glu Pro Cys 
545                 550                 555                 560 


Thr Arg Lys Lys Gly Ser Ala Ala Arg Ser Phe Ser Glu Arg Glu Leu 
                565                 570                 575     


Ala Glu Val Ala Asp Glu Tyr Met Phe Ser Leu Glu Glu Asn Lys Lys 
            580                 585                 590         


Ser Lys Gly Arg Arg Gln Pro Leu Ser Lys Leu Pro Arg His His Pro 
        595                 600                 605             


Leu Val Leu Gln Glu Cys Val Ser Asp Asp Glu Thr Ser Glu Gln Leu 
    610                 615                 620                 


Thr Pro Glu Glu Glu Ala Glu Glu Thr Glu Ala Trp Ala Lys Pro Leu 
625                 630                 635                 640 


Ser Gln Leu Trp Gln Asn Arg Pro Pro Asn Phe Glu Ala Glu Lys Glu 
                645                 650                 655     


Phe Asn Glu Thr Met Ala Gln Gln Ala Pro His Cys Ala Val Cys Met 
            660                 665                 670         


Ile Phe Gln Thr Tyr His Gln Val Glu Phe Gly Gly Phe Asn Gln Asn 
        675                 680                 685             


Cys Gly Asn Ala Ser Asp Leu Ala Pro Gln Lys Gln Arg Thr Lys Pro 
    690                 695                 700                 


Leu Ile Pro Glu Met Cys Phe Thr Ser Thr Gly Cys Ser Thr Asp Ile 
705                 710                 715                 720 


Asn Leu Ser Thr Pro Tyr Leu Glu Glu Asp Gly Thr Ser Ile Leu Val 
                725                 730                 735     


Ser Cys Lys Lys Cys Ser Val Arg Val His Ala Ser Cys Tyr Gly Val 
            740                 745                 750         


Pro Pro Ala Lys Ala Ser Glu Asp Trp Met Cys Ser Arg Cys Ser Ala 
        755                 760                 765             


Asn Ala Leu Glu Glu Asp Cys Cys Leu Cys Ser Leu Arg Gly Gly Ala 
    770                 775                 780                 


Leu Gln Arg Ala Asn Asp Asp Arg Trp Val His Val Ser Cys Ala Val 
785                 790                 795                 800 


Ala Ile Leu Glu Ala Arg Phe Val Asn Ile Ala Glu Arg Ser Pro Val 
                805                 810                 815     


Asp Val Ser Lys Ile Pro Leu Pro Arg Phe Lys Leu Lys Cys Ile Phe 
            820                 825                 830         


Cys Lys Lys Arg Arg Lys Arg Thr Ala Gly Cys Cys Val Gln Cys Ser 
        835                 840                 845             


His Gly Arg Cys Pro Thr Ala Phe His Val Ser Cys Ala Gln Ala Ala 
    850                 855                 860                 


Gly Val Met Met Gln Pro Asp Asp Trp Pro Phe Val Val Phe Ile Thr 
865                 870                 875                 880 


Cys Phe Arg His Lys Ile Pro Asn Leu Glu Arg Ala Lys Gly Ala Leu 
                885                 890                 895     


Gln Ser Ile Thr Ala Gly Gln Lys Val Ile Ser Lys His Lys Asn Gly 
            900                 905                 910         


Arg Phe Tyr Gln Cys Glu Val Val Arg Leu Thr Thr Glu Thr Phe Tyr 
        915                 920                 925             


Glu Val Asn Phe Asp Asp Gly Ser Phe Ser Asp Asn Leu Tyr Pro Glu 
    930                 935                 940                 


Asp Ile Val Ser Gln Asp Cys Leu Gln Phe Gly Pro Pro Ala Glu Gly 
945                 950                 955                 960 


Glu Val Val Gln Val Arg Trp Thr Asp Gly Gln Val Tyr Gly Ala Lys 
                965                 970                 975     


Phe Val Ala Ser His Pro Ile Gln Met Tyr Gln Val Glu Phe Glu Asp 
            980                 985                 990         


Gly Ser Gln Leu Val Val Lys Arg  Asp Asp Val Tyr Thr  Leu Asp Glu 
        995                 1000                 1005             


Glu Leu  Pro Lys Arg Val Lys  Ser Arg Leu Ser Val  Ala Ser Asp 
    1010                 1015                 1020             


Met Arg  Phe Asn Glu Ile Phe  Thr Glu Lys Glu Val  Lys Gln Glu 
    1025                 1030                 1035             


Lys Lys  Arg Gln Arg Val Ile  Asn Ser Arg Tyr Arg  Glu Asp Tyr 
    1040                 1045                 1050             


Ile Glu  Pro Ala Leu Tyr Arg  Ala Ile Met Glu 
    1055                 1060                 


<210> 3

<400> 3
000


<210> 4

<400> 4
000


<210> 5
<211> 5675
<212> DNA
<213> Homo sapiens

<400> 5
agggctcggt cgccagcaac cgagcggggc ccggcccgag cggggcctgg gggtgcgacg       60

ccgagggcgg gggagagcgc gccgctgctc ccggaccggg ccgcgcacgc cgcctcagga      120

accatcactg ttgctggagg cacctgacaa atcctagcga atttttggag catctccacc      180

caggaacctc gccatccaga agtgtgcttc ccgcacagct gcagccatgg ggtctgagga      240

ccacggcgcc cagaacccca gctgtaaaat catgacgttt cgcccaacca tggaagaatt      300

taaagacttc aacaaatacg tggcctacat agagtcgcag ggagcccacc gggcgggcct      360

ggccaagatc atccccccga aggagtggaa gccgcggcag acgtatgatg acatcgacga      420

cgtggtgatc ccggcgccca tccagcaggt ggtgacgggc cagtcgggcc tcttcacgca      480

gtacaatatc cagaagaagg ccatgacagt gggcgagtac cgccgcctgg ccaacagcga      540

gaagtactgt accccgcggc accaggactt tgatgacctt gaacgcaaat actggaagaa      600

cctcaccttt gtctccccga tctacggggc tgacatcagc ggctctttgt atgatgacga      660

cgtggcccag tggaacatcg ggagcctccg gaccatcctg gacatggtgg agcgcgagtg      720

cggcaccatc atcgagggcg tgaacacgcc ctacctgtac ttcggcatgt ggaagaccac      780

cttcgcctgg cacaccgagg acatggacct gtacagcatc aactacctgc actttgggga      840

gcctaagtcc tggtacgcca tcccaccaga gcacggcaag cgcctggagc ggctggccat      900

cggcttcttc cccgggagct cgcagggctg cgacgccttc ctgcggcata agatgaccct      960

catctcgccc atcatcctga agaagtacgg gatccccttc agccggatca cgcaggaggc     1020

cggggaattc atgatcacat ttccctacgg ctaccacgcc ggcttcaatc acgggttcaa     1080

ctgcgcagaa tctaccaact tcgccaccct gcggtggatt gactacggca aagtggccac     1140

tcagtgcacg tgccggaagg acatggtcaa gatctccatg gacgtgttcg tgcgcatcct     1200

gcagcccgag cgctacgagc tgtggaagca gggcaaggac ctcacggtgc tggaccacac     1260

gcggcccacg gcgctcacca gccccgagct gagctcctgg agtgcatccc gggcctcgct     1320

gaaggccaag ctcctccgca ggtctcaccg gaaacggagc cagcccaaga agccgaagcc     1380

cgaagacccc aagttccctg gggagggtac ggctggggca gcgctcctag aggaggctgg     1440

gggcagcgtg aaggaggagg ctgggccgga ggttgacccc gaggaggagg aggaggagcc     1500

gcagccactg ccacacggcc gggaggccga gggcgcagaa gaggacggga ggggcaagct     1560

gcggccaacc aaggccaaga gcgagcggaa gaagaagagc ttcggcctgc tgcccccaca     1620

gctgccgccc ccgcctgctc acttcccctc agaggaggcg ctgtggctgc catccccact     1680

ggagcccccg gtgctgggcc caggccctgc agccatggag gagagccccc tgccggcacc     1740

ccttaatgtc gtgccccctg aggtgcccag tgaggagcta gaggccaagc ctcggcccat     1800

catccccatg ctgtacgtgg tgccgcggcc gggcaaggca gccttcaacc aggagcacgt     1860

gtcctgccag caggcctttg agcactttgc ccagaagggt ccgacctgga aggaaccagt     1920

ttcccccatg gagctgacgg ggccagagga cggtgcagcc agcagtgggg caggtcgcat     1980

ggagaccaaa gcccgggccg gagaggggca ggcaccgtcc acattttcca aattgaagat     2040

ggagatcaag aagagccggc gccatcccct gggccggccg cccacccggt ccccactgtc     2100

ggtggtgaag caggaggcct caagtgacga ggaggcatcc cctttctccg gggaggaaga     2160

tgtgagtgac ccggacgcct tgaggccgct gctgtctctg cagtggaaga acagggcggc     2220

cagcttccag gccgagagga agttcaacgc agcggctgcg cgcacggagc cctactgcgc     2280

catctgcacg ctcttctacc cctactgcca ggccctacag actgagaagg aggcacccat     2340

agcctccctc ggagagggct gcccggccac attaccctcc aaaagccgtc agaagacccg     2400

accgctcatc cctgagatgt gcttcacctc tggcggtgag aacacggagc cgctgcctgc     2460

caactcctac atcggcgacg acgggaccag ccccctgatc gcctgcggca agtgctgcct     2520

gcaggtccat gccagttgct atggcatccg tcccgagctg gtcaatgaag gctggacgtg     2580

ttcccggtgc gcggcccacg cctggactgc ggagtgctgc ctgtgcaacc tgcgaggagg     2640

tgcgctgcag atgaccaccg ataggaggtg gatccacgtg atctgtgcca tcgcagtccc     2700

cgaggcgcgc ttcctgaacg tgattgagcg ccaccctgtg gacatcagcg ccatccccga     2760

gcagcggtgg aagctgaaat gcgtgtactg ccggaagcgg atgaagaagg tgtcaggtgc     2820

ctgtatccag tgctcctacg agcactgctc cacgtccttc cacgtgacct gcgcccacgc     2880

cgcaggcgtg ctcatggagc cggacgactg gccctatgtg gtctccatca cctgcctcaa     2940

gcacaagtcg gggggtcacg ctgtccaact cctgagggcc gtgtccctag gccaggtggt     3000

catcaccaag aaccgcaacg ggctgtacta ccgctgtcgc gtcatcggtg ccgcctcgca     3060

gacctgctac gaagtgaact tcgacgatgg ctcctacagc gacaacctgt accctgagag     3120

catcacgagt agggactgtg tccagctggg acccccttcc gagggggagc tggtggagct     3180

ccggtggact gacggcaacc tctacaaggc caagttcatc tcctccgtca ccagccacat     3240

ctaccaggtg gagtttgagg acgggtccca gctgacggtg aagcgtgggg acatcttcac     3300

cctggaggag gagctgccca agagggtccg ctctcggctg tcactgagca cgggggcacc     3360

gcaggagccc gccttctcgg gggaggaggc caaggccgcc aagcgcccgc gtgtgggcac     3420

cccgcttgcc acggaggact ccgggcggag ccaggactac gtggccttcg tggagagcct     3480

cctgcaggtg cagggccggc ccggagcccc cttctaggac agctggccgc tcaggcgacc     3540

ctcagcccgg cggggaggcc atggcatgcc ccgggcgttc gcttgctgtg aattcctgtc     3600

ctcgtgtccc cgacccccga gaggccacct ccaagccgcg ggtgccccct agggcgacag     3660

gagccagcgg gacgccgcac gcggccccag actcagggag cagggccagg cgggctcggg     3720

ggccggccag gggagcaccc cactcaacta ctcagaattt taaaccatgt aagctctctt     3780

cttctcgaaa aggtgctact gcaatgccct actgagcaac ctttgagatt gtcacttctg     3840

tacataaacc acctttgtga ggctctttct ataaatacat attgtttaaa aaaaagcaag     3900

aaaaaaagga aaacaaagga aaatatcccc aaagttgttt tctagatttg tggctttaag     3960

aaaaacaaaa caaaacaaac acattgtttt tctcagaacc aggattctct gagaggtcag     4020

agcatctcgc tgtttttttg ttgttgtttt aaaatattat gatttggcta cagaccaggc     4080

agggaaagag acccggtaat tggagggtga gcctcggggg gggggcagga cgccccggtt     4140

tcggcacagc ccggtcactc acggcctcgc tctcgcctca ccccggctcc tgggctttga     4200

tggtctggtg ccagtgcctg tgcccactct gtgcctgctg ggaggaggcc caggctctct     4260

ggtggccgcc cctgtgcacc tggccagggg aagcccgggg gtctggggcc tccctccgtc     4320

tgcgcccacc tttgcagaat aaactctctc ctggggtttg tctatctttg tttctctcac     4380

ctgagagaaa cgcaggtgtt ccagaggctt ccttgcagac aaagcacccc tgcacctcct     4440

atggctcagg atgagggagg cccccaggcc cttctggttg gtagtgagtg tggacagctt     4500

cccagctctt cgggtacaac cctgagcagg tcgggggaca cagggccgag gcaggccttc     4560

ggggcccctt tcgcctgctt ccgggcaggg acgaggcctg gtgtcctcgc tccacccacc     4620

cacgctgctg tcacctgagg ggaatctgct tcttaggagt gggttgagct gatagagaaa     4680

aaacggcctt cagcccaggc tgggaagcgc cttctccagg tgcctctccc tcaccagctc     4740

tgcacccctc tggggagcct tccccacctt agctgtctcc tgccccaggg agggatggag     4800

gagataattt gcttatatta aaaacaaaaa atggctgagg caggagtttg ggaccagcct     4860

gggctatata gcaagacccc atcactacaa attttttaca aattagctag gtgtggtggt     4920

gcgcacctgt ggtcccagct actcgggagg ctgtggtggg aggattgctt gagtccagga     4980

ggttgaggct gcagtcagct cagattgcac cactgcactc cagcctgggc aacagagcga     5040

gaccctgtct ccaaaaaaaa aaaaaagcaa tgtttatatt ataaaagagt gtcctaacag     5100

tccccgggct agagaggact aaggaaaaca gagagagtgt tacgcaggag caagcctttc     5160

atttccttgg tgggggaggg gggcggttgc cctggagagg gccggggtcg gggaggttgg     5220

ggggtgtcag ccaaaacgtg gaggtgtccc tctgcacgca gccctcgccc ggcgtggcgc     5280

tgacactgta ttcttatgtt gtttgaaaat gctatttata ttgtaaagaa gcgggcgggt     5340

gcccctgctg cccttgtccc ttgggggtca cacccatccc ctggtgggct cctgggcggc     5400

ctgcgcagat gggccacaga agggcaggcc ggagctgcac actctcccca cgaaggtatc     5460

tctgtgtctt actctgtgca aagacgcggc aaaacccagt gccctggttt ttccccaccc     5520

gagatgaagg atacgctgta ttttttgcct aatgtccctg cctctaggtt cataatgaat     5580

taaaggttca tgaacgctgc gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     5640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                                5675


<210> 6
<211> 1096
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Ser Glu Asp His Gly Ala Gln Asn Pro Ser Cys Lys Ile Met 
1               5                   10                  15      


Thr Phe Arg Pro Thr Met Glu Glu Phe Lys Asp Phe Asn Lys Tyr Val 
            20                  25                  30          


Ala Tyr Ile Glu Ser Gln Gly Ala His Arg Ala Gly Leu Ala Lys Ile 
        35                  40                  45              


Ile Pro Pro Lys Glu Trp Lys Pro Arg Gln Thr Tyr Asp Asp Ile Asp 
    50                  55                  60                  


Asp Val Val Ile Pro Ala Pro Ile Gln Gln Val Val Thr Gly Gln Ser 
65                  70                  75                  80  


Gly Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val Gly 
                85                  90                  95      


Glu Tyr Arg Arg Leu Ala Asn Ser Glu Lys Tyr Cys Thr Pro Arg His 
            100                 105                 110         


Gln Asp Phe Asp Asp Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr Phe 
        115                 120                 125             


Val Ser Pro Ile Tyr Gly Ala Asp Ile Ser Gly Ser Leu Tyr Asp Asp 
    130                 135                 140                 


Asp Val Ala Gln Trp Asn Ile Gly Ser Leu Arg Thr Ile Leu Asp Met 
145                 150                 155                 160 


Val Glu Arg Glu Cys Gly Thr Ile Ile Glu Gly Val Asn Thr Pro Tyr 
                165                 170                 175     


Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His Thr Glu Asp 
            180                 185                 190         


Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys Ser 
        195                 200                 205             


Trp Tyr Ala Ile Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu Ala 
    210                 215                 220                 


Ile Gly Phe Phe Pro Gly Ser Ser Gln Gly Cys Asp Ala Phe Leu Arg 
225                 230                 235                 240 


His Lys Met Thr Leu Ile Ser Pro Ile Ile Leu Lys Lys Tyr Gly Ile 
                245                 250                 255     


Pro Phe Ser Arg Ile Thr Gln Glu Ala Gly Glu Phe Met Ile Thr Phe 
            260                 265                 270         


Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu 
        275                 280                 285             


Ser Thr Asn Phe Ala Thr Leu Arg Trp Ile Asp Tyr Gly Lys Val Ala 
    290                 295                 300                 


Thr Gln Cys Thr Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp Val 
305                 310                 315                 320 


Phe Val Arg Ile Leu Gln Pro Glu Arg Tyr Glu Leu Trp Lys Gln Gly 
                325                 330                 335     


Lys Asp Leu Thr Val Leu Asp His Thr Arg Pro Thr Ala Leu Thr Ser 
            340                 345                 350         


Pro Glu Leu Ser Ser Trp Ser Ala Ser Arg Ala Ser Leu Lys Ala Lys 
        355                 360                 365             


Leu Leu Arg Arg Ser His Arg Lys Arg Ser Gln Pro Lys Lys Pro Lys 
    370                 375                 380                 


Pro Glu Asp Pro Lys Phe Pro Gly Glu Gly Thr Ala Gly Ala Ala Leu 
385                 390                 395                 400 


Leu Glu Glu Ala Gly Gly Ser Val Lys Glu Glu Ala Gly Pro Glu Val 
                405                 410                 415     


Asp Pro Glu Glu Glu Glu Glu Glu Pro Gln Pro Leu Pro His Gly Arg 
            420                 425                 430         


Glu Ala Glu Gly Ala Glu Glu Asp Gly Arg Gly Lys Leu Arg Pro Thr 
        435                 440                 445             


Lys Ala Lys Ser Glu Arg Lys Lys Lys Ser Phe Gly Leu Leu Pro Pro 
    450                 455                 460                 


Gln Leu Pro Pro Pro Pro Ala His Phe Pro Ser Glu Glu Ala Leu Trp 
465                 470                 475                 480 


Leu Pro Ser Pro Leu Glu Pro Pro Val Leu Gly Pro Gly Pro Ala Ala 
                485                 490                 495     


Met Glu Glu Ser Pro Leu Pro Ala Pro Leu Asn Val Val Pro Pro Glu 
            500                 505                 510         


Val Pro Ser Glu Glu Leu Glu Ala Lys Pro Arg Pro Ile Ile Pro Met 
        515                 520                 525             


Leu Tyr Val Val Pro Arg Pro Gly Lys Ala Ala Phe Asn Gln Glu His 
    530                 535                 540                 


Val Ser Cys Gln Gln Ala Phe Glu His Phe Ala Gln Lys Gly Pro Thr 
545                 550                 555                 560 


Trp Lys Glu Pro Val Ser Pro Met Glu Leu Thr Gly Pro Glu Asp Gly 
                565                 570                 575     


Ala Ala Ser Ser Gly Ala Gly Arg Met Glu Thr Lys Ala Arg Ala Gly 
            580                 585                 590         


Glu Gly Gln Ala Pro Ser Thr Phe Ser Lys Leu Lys Met Glu Ile Lys 
        595                 600                 605             


Lys Ser Arg Arg His Pro Leu Gly Arg Pro Pro Thr Arg Ser Pro Leu 
    610                 615                 620                 


Ser Val Val Lys Gln Glu Ala Ser Ser Asp Glu Glu Ala Ser Pro Phe 
625                 630                 635                 640 


Ser Gly Glu Glu Asp Val Ser Asp Pro Asp Ala Leu Arg Pro Leu Leu 
                645                 650                 655     


Ser Leu Gln Trp Lys Asn Arg Ala Ala Ser Phe Gln Ala Glu Arg Lys 
            660                 665                 670         


Phe Asn Ala Ala Ala Ala Arg Thr Glu Pro Tyr Cys Ala Ile Cys Thr 
        675                 680                 685             


Leu Phe Tyr Pro Tyr Cys Gln Ala Leu Gln Thr Glu Lys Glu Ala Pro 
    690                 695                 700                 


Ile Ala Ser Leu Gly Glu Gly Cys Pro Ala Thr Leu Pro Ser Lys Ser 
705                 710                 715                 720 


Arg Gln Lys Thr Arg Pro Leu Ile Pro Glu Met Cys Phe Thr Ser Gly 
                725                 730                 735     


Gly Glu Asn Thr Glu Pro Leu Pro Ala Asn Ser Tyr Ile Gly Asp Asp 
            740                 745                 750         


Gly Thr Ser Pro Leu Ile Ala Cys Gly Lys Cys Cys Leu Gln Val His 
        755                 760                 765             


Ala Ser Cys Tyr Gly Ile Arg Pro Glu Leu Val Asn Glu Gly Trp Thr 
    770                 775                 780                 


Cys Ser Arg Cys Ala Ala His Ala Trp Thr Ala Glu Cys Cys Leu Cys 
785                 790                 795                 800 


Asn Leu Arg Gly Gly Ala Leu Gln Met Thr Thr Asp Arg Arg Trp Ile 
                805                 810                 815     


His Val Ile Cys Ala Ile Ala Val Pro Glu Ala Arg Phe Leu Asn Val 
            820                 825                 830         


Ile Glu Arg His Pro Val Asp Ile Ser Ala Ile Pro Glu Gln Arg Trp 
        835                 840                 845             


Lys Leu Lys Cys Val Tyr Cys Arg Lys Arg Met Lys Lys Val Ser Gly 
    850                 855                 860                 


Ala Cys Ile Gln Cys Ser Tyr Glu His Cys Ser Thr Ser Phe His Val 
865                 870                 875                 880 


Thr Cys Ala His Ala Ala Gly Val Leu Met Glu Pro Asp Asp Trp Pro 
                885                 890                 895     


Tyr Val Val Ser Ile Thr Cys Leu Lys His Lys Ser Gly Gly His Ala 
            900                 905                 910         


Val Gln Leu Leu Arg Ala Val Ser Leu Gly Gln Val Val Ile Thr Lys 
        915                 920                 925             


Asn Arg Asn Gly Leu Tyr Tyr Arg Cys Arg Val Ile Gly Ala Ala Ser 
    930                 935                 940                 


Gln Thr Cys Tyr Glu Val Asn Phe Asp Asp Gly Ser Tyr Ser Asp Asn 
945                 950                 955                 960 


Leu Tyr Pro Glu Ser Ile Thr Ser Arg Asp Cys Val Gln Leu Gly Pro 
                965                 970                 975     


Pro Ser Glu Gly Glu Leu Val Glu Leu Arg Trp Thr Asp Gly Asn Leu 
            980                 985                 990         


Tyr Lys Ala Lys Phe Ile Ser Ser  Val Thr Ser His Ile  Tyr Gln Val 
        995                 1000                 1005             


Glu Phe  Glu Asp Gly Ser Gln  Leu Thr Val Lys Arg  Gly Asp Ile 
    1010                 1015                 1020             


Phe Thr  Leu Glu Glu Glu Leu  Pro Lys Arg Val Arg  Ser Arg Leu 
    1025                 1030                 1035             


Ser Leu  Ser Thr Gly Ala Pro  Gln Glu Pro Ala Phe  Ser Gly Glu 
    1040                 1045                 1050             


Glu Ala  Lys Ala Ala Lys Arg  Pro Arg Val Gly Thr  Pro Leu Ala 
    1055                 1060                 1065             


Thr Glu  Asp Ser Gly Arg Ser  Gln Asp Tyr Val Ala  Phe Val Glu 
    1070                 1075                 1080             


Ser Leu  Leu Gln Val Gln Gly  Arg Pro Gly Ala Pro  Phe 
    1085                 1090                 1095     


<210> 7
<211> 4687
<212> DNA
<213> Homo sapiens

<400> 7
gccataggtg cgcgtcggcg cccaggagga cgtgtggcgc gtggactaca tcaggtccag       60

ccctgcggga ccccagccag cgcttccggg caaggttctg tgcacctgtt ttctccttct      120

acgcgagtat ctttcccctc cggaaagaat gggatatgcc tgtgtccaaa ggacaagaag      180

atgcgcgcca gcaagcctaa gttaaccaca gcgcggaagt tgagcccaaa gcaagagcgt      240

gccgggcacc tttaagctgt ttgtaagccc acgtgactca ccaagtgcgg gccccagcgg      300

tcacgtgacg gcgcgcgcgc cctcgcgcag ggagagccgg cggtgcgcgc gccttcgccg      360

ctgcctccca cccaccccct cgacgggagg gtgaggcgcg gcgcagtgat cgggcggccg      420

gggtcctgtg cgcgtgcgca gcgaacagct gtcacctagt gcggaacaag tctcccaaat      480

ttcccaaatc tccctgggcc ggaggccact gtcttctctt cctcctccac cgagtcgtgc      540

tctcgcccca acccgcgcgc cagacactgc cctaaccatc atggaggtgg ccgaggtgga      600

aagtcctctg aaccccagct gtaagataat gaccttcaga ccctccatgg aggagttccg      660

ggagttcaac aaataccttg catacatgga gtctaaagga gcccatcgtg cgggtcttgc      720

aaaggtgatt cctcctaagg agtggaagcc aagacagtgc tatgatgaca ttgataattt      780

gctcattcca gcaccaattc agcagatggt cacagggcag tcaggactgt tcactcagta      840

caacatccag aaaaaagcga tgactgtgaa ggagttcagg cagctggcca acagtggcaa      900

atattgtact ccaagatact tggattacga agatttggag cgcaagtact ggaagaactt      960

aacttttgtg gcacctatct atggtgcaga tattaatggg agcatatatg atgagggtgt     1020

ggatgaatgg aacatagctc gcctcaatac agtcttggat gtggttgaag aagagtgtgg     1080

catttctatt gagggtgtaa ataccccata tctctatttt ggcatgtgga agaccacgtt     1140

tgcatggcac accgaagaca tggacctcta tagcattaat tatctccact ttggagagcc     1200

caagtcttgg tatgctatac ctccggagca tggaaaacga cttgaaagac tagctcaagg     1260

ttttttccca agcagctccc aagggtgtga tgcatttctt cgccacaaga tgacattgat     1320

ttctccatca gtattgaaga aatatggtat tccctttgac aagataaccc aggaggctgg     1380

agaattcatg atcactttcc catatggcta ccatgctggt tttaatcatg gtttcaactg     1440

tgcagaatct acaaattttg ctactgtcag atggattgac tatggaaaag ttgccaaatt     1500

gtgcacttgc aggaaagaca tggtgaagat ttcaatggat atctttgtga ggaaatttca     1560

gccagacaga tatcagcttt ggaaacaagg aaaggatata tacaccattg atcacacgaa     1620

gcctactcca gcatccaccc ctgaagtaaa agcatggctg cagaggagga ggaaagtaag     1680

aaaagcatcc cgaagcttcc agtgtgctag gtctacctct aaaaggccta aggctgatga     1740

ggaagaggaa gtgtcagatg aagtcgatgg ggcagaggtc cctaaccccg actcagtcac     1800

agatgacctc aaggtcagtg aaaagtcaga agcagcagtg aagctgagga acacagaagc     1860

atcttcagaa gaagagtcat ctgctagcag gatgcaggtg gagcagaatt tatcagatca     1920

tatcaaactc tcaggaaaca gctgcttaag tacatctgta acagaagaca taaaaactga     1980

ggatgacaaa gcttatgcat atagaagtgt accttctata tccagtgagg ctgatgattc     2040

cattccattg tctagtggct atgagaagcc cgagaaatca gacccatccg agctttcatg     2100

gccaaagtca cctgagtcat gctcatcagt ggcagagagt aatggtgtgt taacagaggg     2160

agaagagagt gatgtggaga gccatgggaa tggccttgaa cctggggaaa tcccagcggt     2220

ccccagtgga gagagaaata gcttcaaagt ccccagtata gcagagggag agaacaaaac     2280

ctctaagagt tggcgccatc cacttagcag gcctccagca agatctccga tgactcttgt     2340

gaagcagcag gcgccaagtg atgaagaatt gcctgaggtt ctgtccattg aggaggaagt     2400

ggaagaaaca gagtcttggg cgaaacctct catccacctt tggcagacga agtcccctaa     2460

cttcgcagct gagcaagagt ataatgcaac agtggccagg atgaagccac actgtgccat     2520

ctgcactctg ctcatgccgt accacaagcc agatagcagc aatgaagaaa atgatgctag     2580

atgggagaca aaattagatg aagtcgttac atcggaggga aagactaagc ccctcatacc     2640

agagatgtgt tttatttata gtgaagaaaa tatagaatat tctccaccca atgccttcct     2700

tgaagaggat ggaacaagtc tccttatttc ctgtgcaaag tgctgcgtac gggttcatgc     2760

aagttgttat ggtattcctt ctcatgagat ctgtgatgga tggctgtgtg cccggtgcaa     2820

aagaaatgcg tggacagcag aatgctgtct ctgcaatttg agaggaggtg ctcttaagca     2880

aacgaagaac aataagtggg cccatgtcat gtgcgccgtt gcggtcccag aagttcgatt     2940

cactaatgtc ccagaaagga cacaaataga tgtaggcaga atacctttac agaggttaaa     3000

attgaaatgc atcttctgca gacaccgggt taagagggtc tctggagcct gcatccagtg     3060

ttcctacggt cgctgcccgg cctccttcca tgtcacttgt gcccatgctg ctggggtact     3120

gatggagcct gatgactggc cttatgtggt gaacattaca tgctttcgac ataaggtcaa     3180

ccccaacgtg aagtccaagg cttgcgagaa ggtcatttcc gtgggtcaaa cggtcatcac     3240

gaagcatcgg aacacccggt attacagttg cagagtgatg gctgtgacat cgcagacctt     3300

ctatgaggtc atgtttgatg atggctcctt tagcagagac acatttcctg aggatatcgt     3360

gagccgagac tgtctgaagc tgggcccacc tgctgaggga gaagtcgtcc aagtcaagtg     3420

gcccgatggc aaactctatg gagcaaaata ttttggatca aatattgccc acatgtacca     3480

ggttgagttt gaagatggat cccagatagc aatgaagaga gaggacatct acactttaga     3540

tgaagagtta cccaagagag tgaaagctcg attttccaca gcctctgaca tgcgatttga     3600

agacacgttt tatggagcag acattatcca aggggagaga aagagacaaa gagtgctgag     3660

ctccaggttt aagaatgaat atgtggccga ccctgtatac cgcacttttt tgaagagctc     3720

tttccagaag aagtgccaga agagacagta gtctgcatac atcgctgcag gccacagagc     3780

agcttgggtt ggaagagaga agatgaaggg acatccttgg ggctgtgccg tgagttttgc     3840

tggcataggt gacagggtgt gtctctgaca gtggtaaatc gggtttccag agtttggtca     3900

ccaaaaatac aaaatacacc caatgaattg gacgcagcaa tctgaaatca tctctagtct     3960

tgctttcact tgtgagcagt tgtcttctat gatcccaaag aagttttcta agtgaaagga     4020

aatactagtg aatcacccac aaggaaaagc cactgccaca gaggaggcgg gtccccttgt     4080

gcggcttagg gccctgtcag gaaacacacg gggacctctc tctctagctc cagcaggtgg     4140

cacctcggta cccagcgggt agggcgataa tttatatatt ttccacagtc agggaaggac     4200

tctcacttat ttgtttcaaa ttgcagtttt tataaaacat ttttaaaaca caaatggcat     4260

gtatgctaat gagatttacc cgtgtgctat ctgtatttcc cttgtacaga acttttacat     4320

ttttgaatat tcctattact tttgattgtg tctgatggga actgagttgt tggcctttgt     4380

gaaatgaaat ttttggctct tgagaaagaa ttcttatgaa ttgttatgcg aattttatat     4440

atttaaagag ggagatctgg ggctgttatt tttaaacact ttttttcata atacatattc     4500

cgagtagata tttataaaat atatgtttct ttcattatgt gtttgtaaaa ttagagttta     4560

aataaatatg ctttgatgca tagttttgaa ctaatgtaac atgatttttc ttttttaaaa     4620

cagcctgaaa atgtactagt gtttaaaaat aaagatttcc attttctcca aaaaaaaaaa     4680

aaaaaaa                                                               4687


<210> 8
<211> 1056
<212> PRT
<213> Homo sapiens

<400> 8
Met Glu Val Ala Glu Val Glu Ser Pro Leu Asn Pro Ser Cys Lys Ile 
1               5                   10                  15      


Met Thr Phe Arg Pro Ser Met Glu Glu Phe Arg Glu Phe Asn Lys Tyr 
            20                  25                  30          


Leu Ala Tyr Met Glu Ser Lys Gly Ala His Arg Ala Gly Leu Ala Lys 
        35                  40                  45              


Val Ile Pro Pro Lys Glu Trp Lys Pro Arg Gln Cys Tyr Asp Asp Ile 
    50                  55                  60                  


Asp Asn Leu Leu Ile Pro Ala Pro Ile Gln Gln Met Val Thr Gly Gln 
65                  70                  75                  80  


Ser Gly Leu Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val 
                85                  90                  95      


Lys Glu Phe Arg Gln Leu Ala Asn Ser Gly Lys Tyr Cys Thr Pro Arg 
            100                 105                 110         


Tyr Leu Asp Tyr Glu Asp Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr 
        115                 120                 125             


Phe Val Ala Pro Ile Tyr Gly Ala Asp Ile Asn Gly Ser Ile Tyr Asp 
    130                 135                 140                 


Glu Gly Val Asp Glu Trp Asn Ile Ala Arg Leu Asn Thr Val Leu Asp 
145                 150                 155                 160 


Val Val Glu Glu Glu Cys Gly Ile Ser Ile Glu Gly Val Asn Thr Pro 
                165                 170                 175     


Tyr Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His Thr Glu 
            180                 185                 190         


Asp Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys 
        195                 200                 205             


Ser Trp Tyr Ala Ile Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu 
    210                 215                 220                 


Ala Gln Gly Phe Phe Pro Ser Ser Ser Gln Gly Cys Asp Ala Phe Leu 
225                 230                 235                 240 


Arg His Lys Met Thr Leu Ile Ser Pro Ser Val Leu Lys Lys Tyr Gly 
                245                 250                 255     


Ile Pro Phe Asp Lys Ile Thr Gln Glu Ala Gly Glu Phe Met Ile Thr 
            260                 265                 270         


Phe Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala 
        275                 280                 285             


Glu Ser Thr Asn Phe Ala Thr Val Arg Trp Ile Asp Tyr Gly Lys Val 
    290                 295                 300                 


Ala Lys Leu Cys Thr Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp 
305                 310                 315                 320 


Ile Phe Val Arg Lys Phe Gln Pro Asp Arg Tyr Gln Leu Trp Lys Gln 
                325                 330                 335     


Gly Lys Asp Ile Tyr Thr Ile Asp His Thr Lys Pro Thr Pro Ala Ser 
            340                 345                 350         


Thr Pro Glu Val Lys Ala Trp Leu Gln Arg Arg Arg Lys Val Arg Lys 
        355                 360                 365             


Ala Ser Arg Ser Phe Gln Cys Ala Arg Ser Thr Ser Lys Arg Pro Lys 
    370                 375                 380                 


Ala Asp Glu Glu Glu Glu Val Ser Asp Glu Val Asp Gly Ala Glu Val 
385                 390                 395                 400 


Pro Asn Pro Asp Ser Val Thr Asp Asp Leu Lys Val Ser Glu Lys Ser 
                405                 410                 415     


Glu Ala Ala Val Lys Leu Arg Asn Thr Glu Ala Ser Ser Glu Glu Glu 
            420                 425                 430         


Ser Ser Ala Ser Arg Met Gln Val Glu Gln Asn Leu Ser Asp His Ile 
        435                 440                 445             


Lys Leu Ser Gly Asn Ser Cys Leu Ser Thr Ser Val Thr Glu Asp Ile 
    450                 455                 460                 


Lys Thr Glu Asp Asp Lys Ala Tyr Ala Tyr Arg Ser Val Pro Ser Ile 
465                 470                 475                 480 


Ser Ser Glu Ala Asp Asp Ser Ile Pro Leu Ser Ser Gly Tyr Glu Lys 
                485                 490                 495     


Pro Glu Lys Ser Asp Pro Ser Glu Leu Ser Trp Pro Lys Ser Pro Glu 
            500                 505                 510         


Ser Cys Ser Ser Val Ala Glu Ser Asn Gly Val Leu Thr Glu Gly Glu 
        515                 520                 525             


Glu Ser Asp Val Glu Ser His Gly Asn Gly Leu Glu Pro Gly Glu Ile 
    530                 535                 540                 


Pro Ala Val Pro Ser Gly Glu Arg Asn Ser Phe Lys Val Pro Ser Ile 
545                 550                 555                 560 


Ala Glu Gly Glu Asn Lys Thr Ser Lys Ser Trp Arg His Pro Leu Ser 
                565                 570                 575     


Arg Pro Pro Ala Arg Ser Pro Met Thr Leu Val Lys Gln Gln Ala Pro 
            580                 585                 590         


Ser Asp Glu Glu Leu Pro Glu Val Leu Ser Ile Glu Glu Glu Val Glu 
        595                 600                 605             


Glu Thr Glu Ser Trp Ala Lys Pro Leu Ile His Leu Trp Gln Thr Lys 
    610                 615                 620                 


Ser Pro Asn Phe Ala Ala Glu Gln Glu Tyr Asn Ala Thr Val Ala Arg 
625                 630                 635                 640 


Met Lys Pro His Cys Ala Ile Cys Thr Leu Leu Met Pro Tyr His Lys 
                645                 650                 655     


Pro Asp Ser Ser Asn Glu Glu Asn Asp Ala Arg Trp Glu Thr Lys Leu 
            660                 665                 670         


Asp Glu Val Val Thr Ser Glu Gly Lys Thr Lys Pro Leu Ile Pro Glu 
        675                 680                 685             


Met Cys Phe Ile Tyr Ser Glu Glu Asn Ile Glu Tyr Ser Pro Pro Asn 
    690                 695                 700                 


Ala Phe Leu Glu Glu Asp Gly Thr Ser Leu Leu Ile Ser Cys Ala Lys 
705                 710                 715                 720 


Cys Cys Val Arg Val His Ala Ser Cys Tyr Gly Ile Pro Ser His Glu 
                725                 730                 735     


Ile Cys Asp Gly Trp Leu Cys Ala Arg Cys Lys Arg Asn Ala Trp Thr 
            740                 745                 750         


Ala Glu Cys Cys Leu Cys Asn Leu Arg Gly Gly Ala Leu Lys Gln Thr 
        755                 760                 765             


Lys Asn Asn Lys Trp Ala His Val Met Cys Ala Val Ala Val Pro Glu 
    770                 775                 780                 


Val Arg Phe Thr Asn Val Pro Glu Arg Thr Gln Ile Asp Val Gly Arg 
785                 790                 795                 800 


Ile Pro Leu Gln Arg Leu Lys Leu Lys Cys Ile Phe Cys Arg His Arg 
                805                 810                 815     


Val Lys Arg Val Ser Gly Ala Cys Ile Gln Cys Ser Tyr Gly Arg Cys 
            820                 825                 830         


Pro Ala Ser Phe His Val Thr Cys Ala His Ala Ala Gly Val Leu Met 
        835                 840                 845             


Glu Pro Asp Asp Trp Pro Tyr Val Val Asn Ile Thr Cys Phe Arg His 
    850                 855                 860                 


Lys Val Asn Pro Asn Val Lys Ser Lys Ala Cys Glu Lys Val Ile Ser 
865                 870                 875                 880 


Val Gly Gln Thr Val Ile Thr Lys His Arg Asn Thr Arg Tyr Tyr Ser 
                885                 890                 895     


Cys Arg Val Met Ala Val Thr Ser Gln Thr Phe Tyr Glu Val Met Phe 
            900                 905                 910         


Asp Asp Gly Ser Phe Ser Arg Asp Thr Phe Pro Glu Asp Ile Val Ser 
        915                 920                 925             


Arg Asp Cys Leu Lys Leu Gly Pro Pro Ala Glu Gly Glu Val Val Gln 
    930                 935                 940                 


Val Lys Trp Pro Asp Gly Lys Leu Tyr Gly Ala Lys Tyr Phe Gly Ser 
945                 950                 955                 960 


Asn Ile Ala His Met Tyr Gln Val Glu Phe Glu Asp Gly Ser Gln Ile 
                965                 970                 975     


Ala Met Lys Arg Glu Asp Ile Tyr Thr Leu Asp Glu Glu Leu Pro Lys 
            980                 985                 990         


Arg Val Lys Ala Arg Phe Ser Thr  Ala Ser Asp Met Arg  Phe Glu Asp 
        995                 1000                 1005             


Thr Phe  Tyr Gly Ala Asp Ile  Ile Gln Gly Glu Arg  Lys Arg Gln 
    1010                 1015                 1020             


Arg Val  Leu Ser Ser Arg Phe  Lys Asn Glu Tyr Val  Ala Asp Pro 
    1025                 1030                 1035             


Val Tyr  Arg Thr Phe Leu Lys  Ser Ser Phe Gln Lys  Lys Cys Gln 
    1040                 1045                 1050             


Lys Arg  Gln 
    1055     


<210> 9
<211> 2988
<212> DNA
<213> Homo sapiens

<400> 9
aaggggcggg gccgaagcgg cccagggggc gggcgtttga aatcagtgcc ttagagtaga       60

ccctaaacct cattttatac cttcaagaac caattactta atgtctcttc cgtcttttcc      120

gtccccgacc ccctcccaga ctccttcatt ccggtactgc gtggacggaa agccccgggt      180

agccgacacc acgtccccgg ctagcgggag agagcgtgga aaaggattac accaaactgt      240

ttaaatccaa cgactcctgc ttccatcctt tctcctgagc tagaaccaac aaacctagag      300

agttgggctt cggaaaaact agtgttttca tttaattgga tatgaagaaa gaacaaatat      360

gtacggggca accacgatct ttacaaagaa cataagttcc aggaaagcag gaaccttgtc      420

tctcttgttc actgggtgta tcctctgcat atagaacagt gcctggcaca taataggtgc      480

tgaattttgt tctaaacact gaggacattc tctgctacat ttgggtcgta cccccaggtc      540

tgagtaattc aatagactta agaagacaga gcccagcagc aaccgaaaca taacagagtt      600

gcaggatcag ctaacgtcaa tgcctgggca aagctgctgc ccagagtgga atctcactag      660

tgaataaaca agcccaagaa agattatcat ctcatttgca aaaaaaaaag tacgctggta      720

gatcctgcta cctcatagat aacaccagtc aaattttttt ttaaagtagc attttcctac      780

attgtcaact atctagaaca tacctaaaaa ctaagagttt actgcttatt aaatggaaac      840

tatgaagtct aaggccaact gtgcccagaa tccaaattgt aacataatga tatttcatcc      900

aaccaaagaa gagtttaatg attttgataa atatattgct tacatggaat cccaaggtgc      960

acacagagct ggcttggcta agataattcc acccaaagaa tggaaagcca gagagaccta     1020

tgataatatc agtgaaatct taatagccac tcccctccag caggtggcct ctgggcgggc     1080

aggggtgttt actcaatacc ataaaaaaaa gaaagccatg actgtggggg agtatcgcca     1140

tttggcaaac agtaaaaaat atcagactcc accacaccag aatttcgaag atttggagcg     1200

aaaatactgg aagaaccgca tctataattc accgatttat ggtgctgaca tcagtggctc     1260

cttgtttgat gaaaacacta aacaatggaa tcttgggcac ctgggaacaa ttcaggacct     1320

gctggaaaag gaatgtgggg ttgtcataga aggcgtcaat acaccctact tgtactttgg     1380

catgtggaaa accacgtttg cttggcatac agaggacatg gacctttaca gcatcaacta     1440

cctgcacctt ggggagccca aaacttggta tgtggtgccc ccagaacatg gccagcgcct     1500

ggaacgcctg gccagggagc tcttcccagg cagttcccgg ggttgtgggg ccttcctgcg     1560

gcacaaggtg gccctcatct cgcctacagt tctcaaggaa aatgggattc ccttcaatcg     1620

cataactcag gaggctggag agttcatggt gacctttccc tatggctacc atgctggctt     1680

caaccatggt ttcaactgcg cagaggccat caattttgcc actccgcgat ggattgatta     1740

tggcaaaatg gcctcccagt gtagctgtgg ggaggcaagg gtgacctttt ccatggatgc     1800

cttcgtgcgc atcctgcaac ctgaacgcta tgacctgtgg aaacgtgggc aagaccgggc     1860

agttgtggac cacatggagc ccagggtacc agccagccaa gagctgagca cccagaagga     1920

agtccagtta cccaggagag cagcgctggg cctgagacaa ctcccttccc actgggcccg     1980

gcattcccct tggcctatgg ctgcccgcag tgggacacgg tgccacaccc ttgtgtgctc     2040

ttcactccca cgccgatctg cagttagtgg cactgctacg cagccccggg ctgctgctgt     2100

ccacagctct aagaagccca gctcaactcc atcatccacc cctggtccat ctgcacagat     2160

tatccacccg tcaaatggca gacgtggtcg tggtcgccct cctcagaaac tgagagctca     2220

ggagctgacc ctccagactc cagccaagag gcccctcttg gcgggcacaa catgcacagc     2280

ttcgggccca gaacctgagc ccctacctga ggatggggct ttgatggaca agcctgtacc     2340

actgagccca gggctccagc atcctgtcaa ggcttctggg tgcagctggg cccctgtgcc     2400

ctaagtccac gggctgtctt tatatcccac tgccctgctg tgtgacagtt tgatgaaact     2460

ggttacattt acatcccaaa actttggttg agtttgcagg actctaggca tgcatgaaag     2520

agcccccctg gtgatgccct tggatgctgc caagtccatg gtagttttca attttgccat     2580

acttttgttc ttcctaccgg accctggaat gtctttggat attgctaaaa tctatttctg     2640

cagctgaggt tttatccact ggacacattt gtgtgtgaga actaggtctt gttgaggtta     2700

gcgtaacctg gtatatgcaa ctaccatcct ctgggccaac tgtggaagct gctgcacttg     2760

tgaagaatcc tgagctttga ttcctcttca gtctacgcat ttctctcttc ccctccctca     2820

cccccttttt cttataaaac taggttcttt atacagataa ggtcagtaga gttccagaat     2880

aaaagatatg acttttctga gttatttatg tacttaaaat atgttgtcac agtatttgtt     2940

cccaaatata ttaaaggtaa ccaaaatgtt aaaaaaaaaa aaaaaaaa                  2988


<210> 10
<211> 523
<212> PRT
<213> Homo sapiens

<400> 10
Met Glu Thr Met Lys Ser Lys Ala Asn Cys Ala Gln Asn Pro Asn Cys 
1               5                   10                  15      


Asn Ile Met Ile Phe His Pro Thr Lys Glu Glu Phe Asn Asp Phe Asp 
            20                  25                  30          


Lys Tyr Ile Ala Tyr Met Glu Ser Gln Gly Ala His Arg Ala Gly Leu 
        35                  40                  45              


Ala Lys Ile Ile Pro Pro Lys Glu Trp Lys Ala Arg Glu Thr Tyr Asp 
    50                  55                  60                  


Asn Ile Ser Glu Ile Leu Ile Ala Thr Pro Leu Gln Gln Val Ala Ser 
65                  70                  75                  80  


Gly Arg Ala Gly Val Phe Thr Gln Tyr His Lys Lys Lys Lys Ala Met 
                85                  90                  95      


Thr Val Gly Glu Tyr Arg His Leu Ala Asn Ser Lys Lys Tyr Gln Thr 
            100                 105                 110         


Pro Pro His Gln Asn Phe Glu Asp Leu Glu Arg Lys Tyr Trp Lys Asn 
        115                 120                 125             


Arg Ile Tyr Asn Ser Pro Ile Tyr Gly Ala Asp Ile Ser Gly Ser Leu 
    130                 135                 140                 


Phe Asp Glu Asn Thr Lys Gln Trp Asn Leu Gly His Leu Gly Thr Ile 
145                 150                 155                 160 


Gln Asp Leu Leu Glu Lys Glu Cys Gly Val Val Ile Glu Gly Val Asn 
                165                 170                 175     


Thr Pro Tyr Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His 
            180                 185                 190         


Thr Glu Asp Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Leu Gly Glu 
        195                 200                 205             


Pro Lys Thr Trp Tyr Val Val Pro Pro Glu His Gly Gln Arg Leu Glu 
    210                 215                 220                 


Arg Leu Ala Arg Glu Leu Phe Pro Gly Ser Ser Arg Gly Cys Gly Ala 
225                 230                 235                 240 


Phe Leu Arg His Lys Val Ala Leu Ile Ser Pro Thr Val Leu Lys Glu 
                245                 250                 255     


Asn Gly Ile Pro Phe Asn Arg Ile Thr Gln Glu Ala Gly Glu Phe Met 
            260                 265                 270         


Val Thr Phe Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn 
        275                 280                 285             


Cys Ala Glu Ala Ile Asn Phe Ala Thr Pro Arg Trp Ile Asp Tyr Gly 
    290                 295                 300                 


Lys Met Ala Ser Gln Cys Ser Cys Gly Glu Ala Arg Val Thr Phe Ser 
305                 310                 315                 320 


Met Asp Ala Phe Val Arg Ile Leu Gln Pro Glu Arg Tyr Asp Leu Trp 
                325                 330                 335     


Lys Arg Gly Gln Asp Arg Ala Val Val Asp His Met Glu Pro Arg Val 
            340                 345                 350         


Pro Ala Ser Gln Glu Leu Ser Thr Gln Lys Glu Val Gln Leu Pro Arg 
        355                 360                 365             


Arg Ala Ala Leu Gly Leu Arg Gln Leu Pro Ser His Trp Ala Arg His 
    370                 375                 380                 


Ser Pro Trp Pro Met Ala Ala Arg Ser Gly Thr Arg Cys His Thr Leu 
385                 390                 395                 400 


Val Cys Ser Ser Leu Pro Arg Arg Ser Ala Val Ser Gly Thr Ala Thr 
                405                 410                 415     


Gln Pro Arg Ala Ala Ala Val His Ser Ser Lys Lys Pro Ser Ser Thr 
            420                 425                 430         


Pro Ser Ser Thr Pro Gly Pro Ser Ala Gln Ile Ile His Pro Ser Asn 
        435                 440                 445             


Gly Arg Arg Gly Arg Gly Arg Pro Pro Gln Lys Leu Arg Ala Gln Glu 
    450                 455                 460                 


Leu Thr Leu Gln Thr Pro Ala Lys Arg Pro Leu Leu Ala Gly Thr Thr 
465                 470                 475                 480 


Cys Thr Ala Ser Gly Pro Glu Pro Glu Pro Leu Pro Glu Asp Gly Ala 
                485                 490                 495     


Leu Met Asp Lys Pro Val Pro Leu Ser Pro Gly Leu Gln His Pro Val 
            500                 505                 510         


Lys Ala Ser Gly Cys Ser Trp Ala Pro Val Pro 
        515                 520             


<210> 11
<211> 2339
<212> DNA
<213> Homo sapiens

<400> 11
ccaagcctga gaatcaggag aagcctcaca gtgacacccc caactgagga aactcacaga       60

gctgggacat actctacttc ttcagaaaaa agtatactga ctagagtgga gtccccctgg      120

ggagtcagaa agcctgtgaa agatctcact tgttcaaaag tccaagtgtg aattactgtc      180

tcacagataa accaaagtat tttgaaaaac aaaggggaga aaagaaatta ctccccagaa      240

ctctcaggca tctagaggac acccaagaac gtgggagtca gctgcttctt gtgtgcagcc      300

atgaagtctg tgcactccag tccccagaac acgagtcata ccatcatgac gttttaccca      360

accatggaag aatttgcaga tttcaacaca tatgttgctt acatggagtc ccaaggcgca      420

catcaagctg gccttgccaa ggtaattcca cccaaggaat ggaaagccag acagatgtat      480

gatgatatcg aagacatctt aatagccact cccctccagc aggtgacctc tgggcaggga      540

ggtgtgttta ctcaatacca taaaaagaag aaagccatga gggtggggca gtatcgccgc      600

ttggcaaaca gtaaaaaata tcagactccg ccacaccaga attttgcaga tttggagcaa      660

cgatactgga agagccaccc cggtaatcca ccaatttatg gtgctgatat cagcggctcc      720

ttatttgaag aaagcactaa acaatggaac ctaggacacc tgggaacaat tctggacctg      780

ttggagcagg aatgtggggt tgtcatcgag ggtgtcaaca caccctacct gtactttggc      840

atgtggaaga ccacgtttgc ctggcacaca gaggacatgg acctttacag catcaactac      900

ctgcactttg gggagcccaa aacttggtac gtggtgcccc cagaacatgg tcagcacctg      960

gaacgcctgg ccagggagct cttcccagac atttctcggg gctgtgaggc cttcctgcgg     1020

cacaaagtgg ccctcatctc gcctacagtt ctcaaggaaa atgggattcc cttcaattgc     1080

atgactcagg aggctgggga gttcatggtg acctttccct atggctacca tgctggcttc     1140

aatcacggct tcaactgcgc agaagccatt aattttgcca ctccacgatg gattgattat     1200

ggcaaaatgg cctctcagtg tagctgtggg gagtcgacag tgaccttttc catggacccc     1260

tttgtgcgca ttgtgcaacc cgagagttat gagctctgga aacacaggca agacttggcc     1320

attgtggaac acacagagcc cagggttgca gaaagccaag agctgagcaa ctggagagat     1380

gatatagtac ttagaagagc tgctctgggc ctgaggcttc tcccaaacct cacagcccag     1440

tgtcccacac agcctgtgtc ctcagggcac tgttacaacc caaaaggctg tggcactgat     1500

gctgtgcctg gatccgcatt ccaaagctct gcatatcata cccagaccca gtcacttacc     1560

ctggggatgt cagccagggt tcttctccct tccactggaa gctggggttc tggtcgtggt     1620

cgtggtcgtg gtcaaggtca aggtcgaggt tgcagtcgtg gtcgtggtca tggttgttgt     1680

actcgagaac tggggactga ggagccaact gttcagcctg catccaagag gcgcctttta     1740

atgggtacaa ggagtagagc tcaaggccac aggcctcagc tcccgcttgc caatgatttg     1800

atgacaaatc tgtccctttg agtggtggcc ttcagcatct tgccaaggct tctggctgct     1860

gctgtgtccc tgatcttcaa ctcctggggc ccccactgga tcgtgatgaa accatgcacc     1920

ctggcctgtg cctgctatcc ctcaacagca ctactagtaa tctccctgat gttgtctgca     1980

tgactcctcc caatgtcatt gtgcctttga ttaagttttc cagggacact ggtggggact     2040

ggaactgatt aagttcacca gggacacttg cctggtgaac atgggcaagg ctgtagcaat     2100

ggaccacttt tacggctcta gggttctgac tccaactaag ttttccagaa tctcctgggc     2160

tcctgactca tctgctgggt ctaaagacac tgagtttagg gatattttcc tccaatacat     2220

gatcaatcct ctggatccac ggctatggaa tatggtgaca aatgtcagtg tctctcttat     2280

tccaacccca ggatcagaga agattcttta cctgcagtaa ctgacacatt tccaaggcc      2339


<210> 12
<211> 506
<212> PRT
<213> Homo sapiens

<400> 12
Met Lys Ser Val His Ser Ser Pro Gln Asn Thr Ser His Thr Ile Met 
1               5                   10                  15      


Thr Phe Tyr Pro Thr Met Glu Glu Phe Ala Asp Phe Asn Thr Tyr Val 
            20                  25                  30          


Ala Tyr Met Glu Ser Gln Gly Ala His Gln Ala Gly Leu Ala Lys Val 
        35                  40                  45              


Ile Pro Pro Lys Glu Trp Lys Ala Arg Gln Met Tyr Asp Asp Ile Glu 
    50                  55                  60                  


Asp Ile Leu Ile Ala Thr Pro Leu Gln Gln Val Thr Ser Gly Gln Gly 
65                  70                  75                  80  


Gly Val Phe Thr Gln Tyr His Lys Lys Lys Lys Ala Met Arg Val Gly 
                85                  90                  95      


Gln Tyr Arg Arg Leu Ala Asn Ser Lys Lys Tyr Gln Thr Pro Pro His 
            100                 105                 110         


Gln Asn Phe Ala Asp Leu Glu Gln Arg Tyr Trp Lys Ser His Pro Gly 
        115                 120                 125             


Asn Pro Pro Ile Tyr Gly Ala Asp Ile Ser Gly Ser Leu Phe Glu Glu 
    130                 135                 140                 


Ser Thr Lys Gln Trp Asn Leu Gly His Leu Gly Thr Ile Leu Asp Leu 
145                 150                 155                 160 


Leu Glu Gln Glu Cys Gly Val Val Ile Glu Gly Val Asn Thr Pro Tyr 
                165                 170                 175     


Leu Tyr Phe Gly Met Trp Lys Thr Thr Phe Ala Trp His Thr Glu Asp 
            180                 185                 190         


Met Asp Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys Thr 
        195                 200                 205             


Trp Tyr Val Val Pro Pro Glu His Gly Gln His Leu Glu Arg Leu Ala 
    210                 215                 220                 


Arg Glu Leu Phe Pro Asp Ile Ser Arg Gly Cys Glu Ala Phe Leu Arg 
225                 230                 235                 240 


His Lys Val Ala Leu Ile Ser Pro Thr Val Leu Lys Glu Asn Gly Ile 
                245                 250                 255     


Pro Phe Asn Cys Met Thr Gln Glu Ala Gly Glu Phe Met Val Thr Phe 
            260                 265                 270         


Pro Tyr Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu 
        275                 280                 285             


Ala Ile Asn Phe Ala Thr Pro Arg Trp Ile Asp Tyr Gly Lys Met Ala 
    290                 295                 300                 


Ser Gln Cys Ser Cys Gly Glu Ser Thr Val Thr Phe Ser Met Asp Pro 
305                 310                 315                 320 


Phe Val Arg Ile Val Gln Pro Glu Ser Tyr Glu Leu Trp Lys His Arg 
                325                 330                 335     


Gln Asp Leu Ala Ile Val Glu His Thr Glu Pro Arg Val Ala Glu Ser 
            340                 345                 350         


Gln Glu Leu Ser Asn Trp Arg Asp Asp Ile Val Leu Arg Arg Ala Ala 
        355                 360                 365             


Leu Gly Leu Arg Leu Leu Pro Asn Leu Thr Ala Gln Cys Pro Thr Gln 
    370                 375                 380                 


Pro Val Ser Ser Gly His Cys Tyr Asn Pro Lys Gly Cys Gly Thr Asp 
385                 390                 395                 400 


Ala Val Pro Gly Ser Ala Phe Gln Ser Ser Ala Tyr His Thr Gln Thr 
                405                 410                 415     


Gln Ser Leu Thr Leu Gly Met Ser Ala Arg Val Leu Leu Pro Ser Thr 
            420                 425                 430         


Gly Ser Trp Gly Ser Gly Arg Gly Arg Gly Arg Gly Gln Gly Gln Gly 
        435                 440                 445             


Arg Gly Cys Ser Arg Gly Arg Gly His Gly Cys Cys Thr Arg Glu Leu 
    450                 455                 460                 


Gly Thr Glu Glu Pro Thr Val Gln Pro Ala Ser Lys Arg Arg Leu Leu 
465                 470                 475                 480 


Met Gly Thr Arg Ser Arg Ala Gln Gly His Arg Pro Gln Leu Pro Leu 
                485                 490                 495     


Ala Asn Asp Leu Met Thr Asn Leu Ser Leu 
            500                 505     


<210> 13

<400> 13
000


<210> 14

<400> 14
000


<210> 15

<400> 15
000


<210> 16

<400> 16
000


<210> 17

<400> 17
000


<210> 18

<400> 18
000


<210> 19

<400> 19
000


<210> 20

<400> 20
000


<210> 21
<211> 73
<212> DNA
<213> Homo sapiens

<400> 21
ggccggctgg ggttcctggg gatgggattt gcttcctgtc acaaatcaca ttgccaggga       60

tttccaaccg acc                                                          73


<210> 22
<211> 97
<212> DNA
<213> Homo sapiens

<400> 22
ctcaggtgct ctggctgctt gggttcctgg catgctgatt tgtgacttaa gattaaaatc       60

acattgccag ggattaccac gcaaccacga ccttggc                                97


<210> 23
<211> 90
<212> DNA
<213> Homo sapiens

<400> 23
ccgggcccct gtgagcatct taccggacag tgctggattt cccagcttga ctctaacact       60

gtctggtaac gatgttcaaa ggtgacccgc                                        90


<210> 24
<211> 95
<212> DNA
<213> Homo sapiens

<400> 24
ccagctcggg cagccgtggc catcttactg ggcagcattg gatggagtca ggtctctaat       60

actgcctggt aatgatgacg gcggagccct gcacg                                  95


<210> 25
<211> 68
<212> DNA
<213> Homo sapiens

<400> 25
ccctcgtctt acccagcagt gtttgggtgc ggttgggagt ctctaatact gccgggtaat       60

gatggagg                                                                68


<210> 26
<211> 102
<212> DNA
<213> Homo sapiens

<400> 26
ggtcctctga ctctcttcgg tgacgggtat tcttgggtgg ataatacgga ttacgttgtt       60

attgcttaag aatacgcgta gtcgaggaga gtaccagcgg ca                         102


<210> 27
<211> 20
<212> DNA
<213> Homo sapiens

<400> 27
ctttactcag tacaacatac                                                   20


<210> 28
<211> 349
<212> PRT
<213> Homo sapiens

<400> 28
Ala Ser Glu Ser Glu Thr Leu Asn Pro Ser Ala Arg Ile Met Thr Phe 
1               5                   10                  15      


Tyr Pro Thr Met Glu Glu Phe Arg Asn Phe Ser Arg Tyr Ile Ala Tyr 
            20                  25                  30          


Ile Glu Ser Gln Gly Ala His Arg Ala Gly Leu Ala Lys Val Val Pro 
        35                  40                  45              


Pro Lys Glu Trp Lys Pro Arg Ala Ser Tyr Asp Asp Ile Asp Asp Leu 
    50                  55                  60                  


Val Ile Pro Ala Pro Ile Gln Gln Leu Val Thr Gly Gln Ser Gly Leu 
65                  70                  75                  80  


Phe Thr Gln Tyr Asn Ile Gln Lys Lys Ala Met Thr Val Arg Glu Phe 
                85                  90                  95      


Arg Lys Ile Ala Asn Ser Asp Lys Tyr Cys Thr Pro Arg Tyr Ser Glu 
            100                 105                 110         


Phe Glu Glu Leu Glu Arg Lys Tyr Trp Lys Asn Leu Thr Phe Asn Pro 
        115                 120                 125             


Pro Ile Tyr Gly Ala Asp Val Asn Gly Thr Leu Tyr Glu Lys His Val 
    130                 135                 140                 


Asp Glu Trp Asn Ile Gly Arg Leu Arg Thr Ile Leu Asp Leu Val Glu 
145                 150                 155                 160 


Lys Glu Ser Gly Ile Thr Ile Glu Gly Val Asn Thr Pro Tyr Leu Tyr 
                165                 170                 175     


Phe Gly Met Trp Lys Thr Ser Phe Ala Trp His Thr Glu Asp Met Asp 
            180                 185                 190         


Leu Tyr Ser Ile Asn Tyr Leu His Phe Gly Glu Pro Lys Ser Trp Tyr 
        195                 200                 205             


Ser Val Pro Pro Glu His Gly Lys Arg Leu Glu Arg Leu Ala Lys Gly 
    210                 215                 220                 


Phe Phe Pro Gly Ser Ala Gln Ser Cys Glu Ala Phe Leu Arg His Lys 
225                 230                 235                 240 


Met Thr Leu Ile Ser Pro Leu Met Leu Lys Lys Tyr Gly Ile Pro Phe 
                245                 250                 255     


Asp Lys Val Thr Gln Glu Ala Gly Glu Phe Met Ile Thr Phe Pro Tyr 
            260                 265                 270         


Gly Tyr His Ala Gly Phe Asn His Gly Phe Asn Cys Ala Glu Ser Thr 
        275                 280                 285             


Asn Phe Ala Thr Arg Arg Trp Ile Glu Tyr Gly Lys Gln Ala Val Leu 
    290                 295                 300                 


Cys Ser Cys Arg Lys Asp Met Val Lys Ile Ser Met Asp Val Phe Val 
305                 310                 315                 320 


Arg Lys Phe Gln Pro Glu Arg Tyr Lys Leu Trp Lys Ala Gly Lys Asp 
                325                 330                 335     


Asn Thr Val Ile Asp His Thr Leu Pro Thr Pro Glu Ala 
            340                 345                 


<210> 29
<211> 342
<212> PRT
<213> Bacillus subtilis


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (76)..(76)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (186)..(186)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (260)..(260)
<223> Any amino acid

<400> 29
Xaa Gly Ser Asp Lys Ile His His His His His His Xaa Ser Ala Val 
1               5                   10                  15      


Thr Glu Ser Val Leu Glu Ser Ile Ile Ser Pro Val Thr Xaa Ser Glu 
            20                  25                  30          


Phe Leu Glu Glu Tyr Trp Pro Val Lys Pro Leu Val Ala Arg Gly Glu 
        35                  40                  45              


Val Glu Arg Phe Thr Ser Ile Pro Gly Phe Glu Lys Val Arg Thr Leu 
    50                  55                  60                  


Glu Asn Val Leu Ala Ile Tyr Asn Asn Pro Val Xaa Val Val Gly Asp 
65                  70                  75                  80  


Ala Val Ile Glu Glu Ser Glu Gly Ile Thr Asp Arg Phe Leu Val Ser 
                85                  90                  95      


Pro Ala Glu Ala Leu Glu Trp Tyr Glu Lys Gly Ala Ala Leu Glu Phe 
            100                 105                 110         


Asp Phe Thr Asp Leu Phe Ile Pro Gln Val Arg Arg Trp Ile Glu Lys 
        115                 120                 125             


Leu Lys Ala Glu Leu Arg Leu Pro Ala Gly Thr Ser Ser Lys Ala Ile 
    130                 135                 140                 


Val Tyr Ala Ala Lys Asn Gly Gly Gly Phe Lys Ala His Phe Asp Ala 
145                 150                 155                 160 


Tyr Thr Asn Leu Ile Phe Gln Ile Gln Gly Glu Lys Thr Trp Lys Leu 
                165                 170                 175     


Ala Lys Asn Glu Asn Val Ser Asn Pro Xaa Gln His Tyr Asp Leu Ser 
            180                 185                 190         


Glu Ala Pro Tyr Tyr Pro Asp Asp Leu Gln Ser Tyr Trp Lys Gly Asp 
        195                 200                 205             


Pro Pro Lys Glu Asp Leu Pro Asp Ala Glu Ile Val Asn Leu Thr Pro 
    210                 215                 220                 


Gly Thr Xaa Leu Tyr Leu Pro Arg Gly Leu Trp His Ser Thr Lys Ser 
225                 230                 235                 240 


Asp Gln Ala Thr Leu Ala Leu Asn Ile Thr Phe Gly Gln Pro Ala Trp 
                245                 250                 255     


Leu Asp Leu Xaa Leu Ala Ala Leu Arg Lys Lys Leu Ile Ser Asp Asn 
            260                 265                 270         


Arg Phe Arg Glu Leu Ala Val Asn His Gln Ser Leu His Glu Ser Ser 
        275                 280                 285             


Lys Ser Glu Leu Asn Gly Tyr Leu Glu Ser Leu Ile Gln Thr Leu Ser 
    290                 295                 300                 


Glu Asn Ala Glu Thr Leu Thr Pro Glu Gln Ile Phe Gln Ser Gln Asp 
305                 310                 315                 320 


Ser Asp Phe Asp Pro Tyr Gln Ser Thr Gln Leu Val Phe Arg Gln Leu 
                325                 330                 335     


Leu Thr Ser Tyr Lys Phe 
            340         


<210> 30
<211> 424
<212> PRT
<213> Salmonella enterica

<400> 30
Ser Asn Ala Met Thr Thr Pro Phe Thr His Glu Thr Leu Pro Ala Asp 
1               5                   10                  15      


Pro Lys Ala Ala Ile Arg Gln Met Lys Gln Ala Leu Arg Ala Gln Ile 
            20                  25                  30          


Gly Asp Val Gln Ala Val Phe Asp Arg Leu Ser Ala Thr Ile Ala Ala 
        35                  40                  45              


Arg Val Ala Glu Ile Asn Asp Leu Lys Ala Gln Gly Gln Pro Val Trp 
    50                  55                  60                  


Pro Ile Ile Pro Phe Ser Glu Leu Ala Met Gly Asn Ile Ser Asp Ala 
65                  70                  75                  80  


Thr Arg Ala Glu Val Lys Arg Arg Gly Cys Ala Val Ile Lys Gly His 
                85                  90                  95      


Phe Pro Arg Glu Gln Ala Leu Ala Trp Asp Gln Ser Met Leu Asp Tyr 
            100                 105                 110         


Leu Asp Lys Asn His Phe Asp Glu Val Tyr Lys Gly Pro Gly Asp Asn 
        115                 120                 125             


Phe Phe Gly Thr Leu Ser Ala Ser Arg Pro Glu Ile Tyr Pro Val Tyr 
    130                 135                 140                 


Trp Ser Gln Ala Gln Met Gln Ala Arg Gln Ser Glu Glu Met Ala Leu 
145                 150                 155                 160 


Ala Gln Ser Phe Leu Asn Arg Leu Trp Gln Val Glu His Asp Gly Lys 
                165                 170                 175     


Arg Trp Phe Asn Pro Asp Ile Ser Ile Ile Tyr Pro Asp Arg Ile Arg 
            180                 185                 190         


Arg Arg Pro Pro Gly Thr Thr Ser Lys Gly Leu Gly Ala His Thr Asp 
        195                 200                 205             


Ser Gly Ala Leu Glu Arg Trp Leu Leu Pro Ala Tyr Gln Gln Val Phe 
    210                 215                 220                 


Ala Ser Val Phe Asn Gly Asn Val Glu Gln Tyr Asp Pro Trp Asn Ala 
225                 230                 235                 240 


Ala His Arg Thr Asp Val Glu Glu Tyr Thr Val Asp Asn Thr Thr Lys 
                245                 250                 255     


Cys Ser Val Phe Arg Thr Phe Gln Gly Trp Thr Ala Leu Ser Asp Met 
            260                 265                 270         


Leu Pro Gly Gln Gly Leu Leu His Val Val Pro Ile Pro Glu Ala Met 
        275                 280                 285             


Ala Tyr Ile Leu Leu Arg Pro Leu Leu Asp Asp Val Pro Glu Asp Glu 
    290                 295                 300                 


Leu Cys Gly Val Ala Pro Gly Arg Val Leu Pro Ile Ser Glu Gln Trp 
305                 310                 315                 320 


His Pro Leu Leu Met Ala Ala Leu Thr Ser Ile Pro Pro Leu Glu Ala 
                325                 330                 335     


Gly Asp Ser Val Trp Trp His Cys Asp Val Ile His Ser Val Ala Pro 
            340                 345                 350         


Val Glu Asn Gln Gln Gly Trp Gly Asn Val Met Tyr Ile Pro Ala Ala 
        355                 360                 365             


Pro Met Cys Glu Lys Asn Leu Ala Tyr Ala Arg Lys Val Lys Ala Ala 
    370                 375                 380                 


Leu Glu Thr Gly Ala Ser Pro Gly Asp Phe Pro Arg Glu Asp Tyr Glu 
385                 390                 395                 400 


Thr Thr Trp Glu Gly Arg Phe Thr Leu Arg Asp Leu Asn Ile His Gly 
                405                 410                 415     


Lys Arg Ala Leu Gly Ile Asp Val 
            420                 


<210> 31
<211> 330
<212> PRT
<213> Arabidopsis thaliana

<400> 31
Met Ala Glu Leu Leu Leu Val Glu Thr Pro Ile Pro Gln Gln Lys His 
1               5                   10                  15      


Tyr Glu Ser Lys Pro Phe Pro Ala Val Ile Ser Pro Pro Ser Ala Ser 
            20                  25                  30          


Ile Pro Ile Pro Ala Leu Ser Leu Pro Leu Phe Thr Gln Thr Ile Lys 
        35                  40                  45              


Thr Gln Lys His Tyr Leu Asp Ser Leu Leu His Glu Ser Gly Ala Val 
    50                  55                  60                  


Leu Phe Arg Gly Phe Pro Val Asn Ser Ala Asp Asp Phe Asn Asp Val 
65                  70                  75                  80  


Val Glu Ala Phe Gly Phe Asp Glu Leu Pro Tyr Val Gly Gly Ala Ala 
                85                  90                  95      


Pro Arg Thr Ser Val Val Gly Arg Val Phe Thr Ala Asn Glu Ser Pro 
            100                 105                 110         


Pro Asp Gln Lys Ile Pro Phe His His Glu Met Ala Gln Val Arg Glu 
        115                 120                 125             


Phe Pro Ser Lys Leu Phe Phe Tyr Cys Glu Ile Glu Pro Lys Cys Gly 
    130                 135                 140                 


Gly Glu Thr Pro Ile Val Leu Ser His Val Val Tyr Glu Arg Met Lys 
145                 150                 155                 160 


Asp Lys His Pro Glu Phe Val Gln Arg Leu Glu Glu His Gly Leu Leu 
                165                 170                 175     


Tyr Val Arg Val Leu Gly Glu Asp Asp Asp Pro Ser Ser Pro Ile Gly 
            180                 185                 190         


Arg Gly Trp Lys Ser Thr Phe Leu Thr His Asp Lys Asn Leu Ala Glu 
        195                 200                 205             


Gln Arg Ala Val Asp Leu Gly Met Lys Leu Glu Trp Thr Glu Asp Gly 
    210                 215                 220                 


Gly Ala Lys Thr Val Met Gly Pro Ile Pro Ala Ile Lys Tyr Asp Glu 
225                 230                 235                 240 


Ser Arg Asn Arg Lys Val Trp Phe Asn Ser Met Val Ala Ala Tyr Thr 
                245                 250                 255     


Gly Trp Glu Asp Lys Arg Asn Asp Pro Arg Lys Ala Val Thr Phe Gly 
            260                 265                 270         


Asp Gly Lys Pro Leu Pro Ala Asp Ile Val His Asp Cys Leu Arg Ile 
        275                 280                 285             


Leu Glu Glu Glu Cys Val Ala Val Pro Trp Gln Arg Gly Asp Val Leu 
    290                 295                 300                 


Leu Ile Asp Asn Trp Ala Val Leu His Ser Arg Arg Pro Phe Asp Pro 
305                 310                 315                 320 


Pro Arg Arg Val Leu Ala Ser Leu Cys Lys 
                325                 330 


<210> 32
<211> 283
<212> PRT
<213> Escherichia coli

<400> 32
Met Ser Glu Arg Leu Ser Ile Thr Pro Leu Gly Pro Tyr Ile Gly Ala 
1               5                   10                  15      


Gln Ile Ser Gly Ala Asp Leu Thr Arg Pro Leu Ser Asp Asn Gln Phe 
            20                  25                  30          


Glu Gln Leu Tyr His Ala Val Leu Arg His Gln Val Val Phe Leu Arg 
        35                  40                  45              


Asp Gln Ala Ile Thr Pro Gln Gln Gln Arg Ala Leu Ala Gln Arg Phe 
    50                  55                  60                  


Gly Glu Leu His Ile His Pro Val Tyr Pro His Ala Glu Gly Val Asp 
65                  70                  75                  80  


Glu Ile Ile Val Leu Asp Thr His Asn Asp Asn Pro Pro Asp Asn Asp 
                85                  90                  95      


Asn Trp His Thr Asp Val Thr Phe Ile Glu Thr Pro Pro Ala Gly Ala 
            100                 105                 110         


Ile Leu Ala Ala Lys Glu Leu Pro Ser Thr Gly Gly Asp Thr Leu Trp 
        115                 120                 125             


Thr Ser Gly Ile Ala Ala Tyr Glu Ala Leu Ser Val Pro Phe Arg Gln 
    130                 135                 140                 


Leu Leu Ser Gly Leu Arg Ala Glu His Asp Phe Arg Lys Ser Phe Pro 
145                 150                 155                 160 


Glu Tyr Lys Tyr Arg Lys Thr Glu Glu Glu His Gln Arg Trp Arg Glu 
                165                 170                 175     


Ala Val Ala Lys Asn Pro Pro Leu Leu His Pro Val Val Arg Thr His 
            180                 185                 190         


Pro Val Ser Gly Lys Gln Ala Leu Phe Val Asn Glu Gly Phe Thr Thr 
        195                 200                 205             


Arg Ile Val Asp Val Ser Glu Lys Glu Ser Glu Ala Leu Leu Ser Phe 
    210                 215                 220                 


Leu Phe Ala His Ile Thr Lys Pro Glu Phe Gln Val Arg Trp Arg Trp 
225                 230                 235                 240 


Gln Pro Asn Asp Ile Ala Ile Trp Asp Asn Arg Val Thr Gln His Tyr 
                245                 250                 255     


Ala Asn Ala Asp Tyr Leu Pro Gln Arg Arg Ile Met His Arg Ala Thr 
            260                 265                 270         


Ile Leu Gly Asp Lys Pro Phe Tyr Arg Ala Gly 
        275                 280             


<210> 33
<211> 357
<212> PRT
<213> Streptomyces coelicolor

<400> 33
Met Lys His His His His His His His Ser Asp Tyr Asp Ile Pro Thr 
1               5                   10                  15      


Thr Glu Asn Leu Tyr Phe Gln Gly Ser Ala Ala Asn Ala Ala Gly Pro 
            20                  25                  30          


Ala Ser Arg Tyr Asp Val Thr Leu Asp Gln Ser Asp Ala Glu Leu Val 
        35                  40                  45              


Glu Glu Ile Ala Trp Lys Leu Ala Thr Gln Ala Thr Gly Arg Pro Asp 
    50                  55                  60                  


Asp Ala Glu Trp Val Glu Ala Ala Arg Asn Ala Trp His Ala Trp Pro 
65                  70                  75                  80  


Ala Thr Leu Arg Arg Asp Leu Ala Gly Phe Arg Arg Asp Ser Gly Pro 
                85                  90                  95      


Asp Gly Ala Ile Val Leu Arg Gly Leu Pro Val Asp Ser Met Gly Leu 
            100                 105                 110         


Pro Pro Thr Pro Arg Val Asn Gly Ser Val Gln Arg Glu Ala Ser Leu 
        115                 120                 125             


Gly Ala Ala Val Leu Leu Met Thr Ala Cys Gly Leu Gly Asp Pro Gly 
    130                 135                 140                 


Ala Phe Leu Pro Glu Lys Asn Gly Ala Leu Val Gln Asp Val Val Pro 
145                 150                 155                 160 


Val Pro Gly Met Glu Glu Phe Gln Gly Asn Ala Gly Ser Thr Leu Leu 
                165                 170                 175     


Thr Phe His Asn Glu Asn Ala Phe His Glu His Arg Pro Asp Phe Val 
            180                 185                 190         


Met Leu Leu Cys Leu Arg Ala Asp Pro Thr Gly Arg Ala Gly Leu Arg 
        195                 200                 205             


Thr Ala Cys Val Arg Arg Val Leu Pro Leu Leu Ser Asp Ser Thr Val 
    210                 215                 220                 


Asp Ala Leu Trp Ala Pro Glu Phe Arg Thr Ala Pro Pro Pro Ser Phe 
225                 230                 235                 240 


Gln Leu Ser Gly Pro Glu Glu Ala Pro Ala Pro Val Leu Leu Gly Asp 
                245                 250                 255     


Arg Ser Asp Pro Asp Leu Arg Val Asp Leu Ala Ala Thr Glu Pro Val 
            260                 265                 270         


Thr Glu Arg Ala Ala Glu Ala Leu Arg Glu Leu Gln Ala His Phe Asp 
        275                 280                 285             


Ala Thr Ala Val Thr His Arg Leu Leu Pro Gly Glu Leu Ala Ile Val 
    290                 295                 300                 


Asp Asn Arg Val Thr Val His Gly Arg Thr Glu Phe Thr Pro Arg Tyr 
305                 310                 315                 320 


Asp Gly Thr Asp Arg Trp Leu Gln Arg Thr Phe Val Leu Thr Asp Leu 
                325                 330                 335     


Arg Arg Ser Arg Ala Met Arg Pro Ala Asp Gly Tyr Val Leu Gly Ala 
            340                 345                 350         


Ala Pro Gln Pro Ala 
        355         


<210> 34
<211> 325
<212> PRT
<213> Escherichia coli

<400> 34
Met Asn Ala Leu Thr Ala Val His Asn Asn Ala Val Asp Ser Gly Gln 
1               5                   10                  15      


Asp Tyr Ser Gly Phe Thr Leu Thr Pro Ser Ala Gln Ser Pro Arg Leu 
            20                  25                  30          


Leu Glu Leu Thr Phe Thr Glu Gln Thr Thr Lys Gln Phe Leu Glu Gln 
        35                  40                  45              


Val Ala Glu Trp Pro Val Gln Ala Leu Glu Tyr Lys Ser Phe Leu Arg 
    50                  55                  60                  


Phe Arg Val Gly Lys Ile Leu Asp Asp Leu Cys Ala Asn Gln Leu Gln 
65                  70                  75                  80  


Pro Leu Leu Leu Lys Thr Leu Leu Asn Arg Ala Glu Gly Ala Leu Leu 
                85                  90                  95      


Ile Asn Ala Val Gly Ile Asp Asp Val Ala Gln Ala Asp Glu Met Val 
            100                 105                 110         


Lys Leu Ala Thr Ala Val Ala His Leu Ile Gly Arg Ser Asn Phe Asp 
        115                 120                 125             


Ala Met Ser Gly Gln Tyr Tyr Ala Arg Phe Val Val Lys Asn Val Asp 
    130                 135                 140                 


Asn Ser Asp Ser Tyr Leu Arg Gln Pro His Arg Val Met Glu Leu His 
145                 150                 155                 160 


Asn Asp Gly Thr Tyr Val Glu Glu Ile Thr Asp Tyr Val Leu Met Met 
                165                 170                 175     


Lys Ile Asp Glu Gln Asn Met Gln Gly Gly Asn Ser Leu Leu Leu His 
            180                 185                 190         


Leu Asp Asp Trp Glu His Leu Asp His Tyr Phe Arg His Pro Leu Ala 
        195                 200                 205             


Arg Arg Pro Met Arg Phe Ala Ala Pro Pro Ser Lys Asn Val Ser Lys 
    210                 215                 220                 


Asp Val Phe His Pro Val Phe Asp Val Asp Gln Gln Gly Arg Pro Val 
225                 230                 235                 240 


Met Arg Tyr Ile Asp Gln Phe Val Gln Pro Lys Asp Phe Glu Glu Gly 
                245                 250                 255     


Val Trp Leu Ser Glu Leu Ser Asp Ala Ile Glu Thr Ser Lys Gly Ile 
            260                 265                 270         


Leu Ser Val Pro Val Pro Val Gly Lys Phe Leu Leu Ile Asn Asn Leu 
        275                 280                 285             


Phe Trp Leu His Gly Arg Asp Arg Phe Thr Pro His Pro Asp Leu Arg 
    290                 295                 300                 


Arg Glu Leu Met Arg Gln Arg Gly Tyr Phe Ala Tyr Ala Thr His His 
305                 310                 315                 320 


Tyr Gln Thr His Gln 
                325 


<210> 35
<211> 277
<212> PRT
<213> Geobacillus kaustophilus


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (43)..(43)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (91)..(91)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (124)..(124)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (169)..(169)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (172)..(172)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (257)..(257)
<223> Any amino acid

<400> 35
Xaa Ala Ile Gln Arg Arg Ile Arg Arg Val Lys Thr Val Gln Xaa Thr 
1               5                   10                  15      


Thr Asn Ser Pro Ile His Arg Ser Gly Ser Val Leu Glu Pro Gly Asn 
            20                  25                  30          


Trp Gln Glu Tyr Asp Pro Phe Leu Leu Leu Xaa Glu Asp Ile Phe Glu 
        35                  40                  45              


Arg Gly Thr Phe Asp Val His Pro His Arg Gly Ile Glu Thr Val Thr 
    50                  55                  60                  


Tyr Val Ile Ser Gly Glu Leu Glu His Phe Asp Ser Lys Ala Gly His 
65                  70                  75                  80  


Ser Thr Leu Gly Pro Gly Asp Val Gln Trp Xaa Thr Ala Gly Arg Gly 
                85                  90                  95      


Val Val His Lys Glu Asp Pro Ala Ser Gly Ser Thr Val His Ser Leu 
            100                 105                 110         


Gln Leu Trp Val Asn Leu Pro Ser Ala Tyr Lys Xaa Thr Glu Pro Arg 
        115                 120                 125             


Tyr Gln Asn Leu Arg Ser Lys Asp Xaa Pro Val Arg Lys Glu Glu Gly 
    130                 135                 140                 


Ala Thr Ile Arg Val Phe Ser Gly Ser Ser Lys Gly Val Lys Ala Pro 
145                 150                 155                 160 


Thr Lys Asn Ile Val Pro Val Thr Xaa Val Glu Xaa Ile Val Glu Pro 
                165                 170                 175     


Gly Thr Thr Val Val Gln Asp Leu Pro Gly His Tyr Asn Gly Phe Leu 
            180                 185                 190         


Tyr Ile Leu Glu Gly Ser Gly Val Phe Gly Ala Asp Asn Ile Glu Gly 
        195                 200                 205             


Lys Ala Gly Gln Ala Leu Phe Phe Ser Arg His Asn Arg Gly Glu Glu 
    210                 215                 220                 


Thr Glu Leu Asn Val Thr Ala Arg Glu Lys Leu Arg Leu Leu Leu Tyr 
225                 230                 235                 240 


Ala Gly Glu Pro Val Asn Glu Pro Val Val Ala Tyr Gly Pro Phe Val 
                245                 250                 255     


Xaa Asn Thr Pro Glu Gln Ile Arg Glu Ala Ile Arg Asp Tyr Gln Glu 
            260                 265                 270         


Gly Arg Phe Gly Arg 
        275         


<210> 36
<211> 324
<212> PRT
<213> Streptomyces clavuligerus

<400> 36
Met Thr Ser Val Asp Cys Thr Ala Tyr Gly Pro Glu Leu Arg Ala Leu 
1               5                   10                  15      


Ala Ala Arg Leu Pro Arg Thr Pro Arg Ala Asp Leu Tyr Ala Phe Leu 
            20                  25                  30          


Asp Ala Ala His Thr Ala Ala Ala Ser Leu Pro Gly Ala Leu Ala Thr 
        35                  40                  45              


Ala Leu Asp Thr Phe Asn Ala Glu Gly Ser Glu Asp Gly His Leu Leu 
    50                  55                  60                  


Leu Arg Gly Leu Pro Val Glu Ala Asp Ala Asp Leu Pro Thr Thr Pro 
65                  70                  75                  80  


Ser Ser Thr Pro Ala Pro Glu Asp Arg Ser Leu Leu Thr Met Glu Ala 
                85                  90                  95      


Met Leu Gly Leu Val Gly Arg Arg Leu Gly Leu His Thr Gly Tyr Arg 
            100                 105                 110         


Glu Leu Arg Ser Gly Thr Val Tyr His Asp Val Tyr Pro Ser Pro Gly 
        115                 120                 125             


Ala His His Leu Ser Ser Glu Thr Ser Glu Thr Leu Leu Glu Phe His 
    130                 135                 140                 


Thr Glu Met Ala Tyr His Arg Leu Gln Pro Asn Tyr Val Met Leu Ala 
145                 150                 155                 160 


Cys Ser Arg Ala Asp His Glu Arg Thr Ala Ala Thr Leu Val Ala Ser 
                165                 170                 175     


Val Arg Lys Ala Leu Pro Leu Leu Asp Glu Arg Thr Arg Ala Arg Leu 
            180                 185                 190         


Leu Asp Arg Arg Met Pro Cys Cys Val Asp Val Ala Phe Arg Gly Gly 
        195                 200                 205             


Val Asp Asp Pro Gly Ala Ile Ala Gln Val Lys Pro Leu Tyr Gly Asp 
    210                 215                 220                 


Ala Asp Asp Pro Phe Leu Gly Tyr Asp Arg Glu Leu Leu Ala Pro Glu 
225                 230                 235                 240 


Asp Pro Ala Asp Lys Glu Ala Val Ala Ala Leu Ser Lys Ala Leu Asp 
                245                 250                 255     


Glu Val Thr Glu Ala Val Tyr Leu Glu Pro Gly Asp Leu Leu Ile Val 
            260                 265                 270         


Asp Asn Phe Arg Thr Thr His Ala Arg Thr Pro Phe Ser Pro Arg Trp 
        275                 280                 285             


Asp Gly Lys Asp Arg Trp Leu His Arg Val Tyr Ile Arg Thr Asp Arg 
    290                 295                 300                 


Asn Gly Gln Leu Ser Gly Gly Glu Arg Ala Gly Asp Val Val Ala Phe 
305                 310                 315                 320 


Thr Pro Arg Gly 
                


<210> 37
<211> 273
<212> PRT
<213> Pectobacterium carotovorum


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (37)..(37)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (142)..(142)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (188)..(188)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (244)..(244)
<223> Any amino acid

<400> 37
Xaa Ser Glu Ile Val Lys Phe Asn Pro Val Xaa Ala Ser Gly Phe Gly 
1               5                   10                  15      


Ala Tyr Ile Asp His Arg Asp Phe Leu Glu Ala Lys Thr Glu Thr Ile 
            20                  25                  30          


Lys Asn Leu Leu Xaa Arg Gln Gly Phe Val Val Val Lys Asn Leu Asp 
        35                  40                  45              


Ile Asp Ser Asp Thr Phe Arg Asp Ile Tyr Ser Ala Tyr Gly Thr Ile 
    50                  55                  60                  


Val Glu Tyr Ala Asp Glu Lys Ile Gly Val Gly Phe Gly Tyr Arg Asp 
65                  70                  75                  80  


Thr Leu Lys Leu Glu Gly Glu Lys Gly Lys Ile Val Thr Gly Arg Gly 
                85                  90                  95      


Gln Leu Pro Phe His Ala Asp Gly Gly Leu Leu Leu Ser Gln Val Asp 
            100                 105                 110         


Gln Val Phe Leu Tyr Ala Ala Glu Ile Lys Asn Val Lys Phe Arg Gly 
        115                 120                 125             


Ala Thr Thr Val Cys Asp His Ala Leu Ala Cys Gln Glu Xaa Pro Ala 
    130                 135                 140                 


His Leu Leu Arg Val Leu Glu Glu Glu Thr Phe Glu Val Arg Val Leu 
145                 150                 155                 160 


Glu Arg Gly Tyr Tyr Val Asp Val Ser Pro Asp Gly Trp Phe Lys Val 
                165                 170                 175     


Pro Val Phe Thr Asp Leu Gly Trp Val Arg Lys Xaa Leu Ile Tyr Phe 
            180                 185                 190         


Pro Phe Asp Glu Gly Gln Pro Ala Ser Trp Glu Pro Arg Ile Val Gly 
        195                 200                 205             


Phe Thr Asp His Glu Thr Gln Ala Phe Phe Gln Glu Leu Gly Ala Phe 
    210                 215                 220                 


Leu Lys Gln Pro Arg Tyr Tyr Tyr Lys His Phe Trp Glu Asp Gly Asp 
225                 230                 235                 240 


Leu Leu Ile Xaa Asp Asn Arg Arg Val Ile His Glu Arg Glu Glu Phe 
                245                 250                 255     


Asn Asp Asp Asp Ile Val Arg Arg Leu Tyr Arg Gly Gln Thr Ala Asp 
            260                 265                 270         


Ile 
    


<210> 38
<211> 354
<212> PRT
<213> Escherichia coli


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (108)..(108)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (143)..(143)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (211)..(211)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (253)..(253)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (265)..(265)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (268)..(268)
<223> Any amino acid

<400> 38
Xaa Gly Ser Ser His His His His His His Gly Ser Xaa Thr Asp Asn 
1               5                   10                  15      


Asn Gln Asn Ser Arg Glu Gln Phe Tyr Gln His Ile Ser Gly Gln Asn 
            20                  25                  30          


Leu Thr Pro Leu Trp Glu Ser Leu His His Leu Val Pro Lys Thr Pro 
        35                  40                  45              


Asn Ala Asn Cys Ala Pro Ala Tyr Trp Asn Tyr Gln Glu Ile Arg Pro 
    50                  55                  60                  


Leu Leu Leu Glu Ser Gly Gly Leu Ile Gly Ala Lys Glu Ala Val Arg 
65                  70                  75                  80  


Arg Val Leu Val Leu Glu Asn Pro Ala Leu Arg Gly Gln Ser Ser Ile 
                85                  90                  95      


Thr Ala Thr Leu Tyr Ala Gly Leu Gln Leu Ile Xaa Pro Gly Glu Val 
            100                 105                 110         


Ala Pro Ser His Arg His Asn Gln Ser Ala Leu Arg Phe Ile Val Glu 
        115                 120                 125             


Gly Lys Gly Ala Phe Thr Ala Val Asp Gly Glu Arg Thr Pro Xaa Asn 
    130                 135                 140                 


Glu Gly Asp Phe Ile Leu Thr Pro Gln Trp Arg Trp His Asp His Gly 
145                 150                 155                 160 


Asn Pro Gly Asp Glu Pro Val Ile Trp Leu Asp Gly Leu Asp Leu Pro 
                165                 170                 175     


Leu Val Asn Ile Leu Gly Cys Gly Phe Ala Glu Asp Tyr Pro Glu Glu 
            180                 185                 190         


Gln Gln Pro Val Thr Arg Lys Glu Gly Asp Tyr Leu Pro Arg Tyr Ala 
        195                 200                 205             


Ala Asn Xaa Leu Pro Leu Arg His Gln Thr Gly Asn Ser Ser Pro Ile 
    210                 215                 220                 


Phe Asn Tyr Arg Tyr Asp Arg Ser Arg Glu Val Leu His Asp Leu Thr 
225                 230                 235                 240 


Arg Leu Gly Asp Ala Asp Glu Trp Asp Gly Tyr Lys Xaa Arg Tyr Val 
                245                 250                 255     


Asn Pro Val Thr Gly Gly Tyr Pro Xaa Pro Ser Xaa Gly Ala Phe Leu 
            260                 265                 270         


Gln Leu Leu Pro Lys Gly Phe Ala Ser Arg Val Ala Arg Thr Thr Asp 
        275                 280                 285             


Ser Thr Ile Tyr His Val Val Glu Gly Ser Gly Gln Val Ile Ile Gly 
    290                 295                 300                 


Asn Glu Thr Phe Ser Phe Ser Ala Lys Asp Ile Phe Val Val Pro Thr 
305                 310                 315                 320 


Trp His Gly Val Ser Phe Gln Thr Thr Gln Asp Ser Val Leu Phe Ser 
                325                 330                 335     


Phe Ser Asp Arg Pro Val Gln Glu Ala Leu Gly Leu Phe Arg Glu Ala 
            340                 345                 350         


Arg Tyr 
        


<210> 39
<211> 216
<212> PRT
<213> Oceanicola granulosus

<400> 39
Met Ser Leu Ala Gln Ile Lys Ser Leu Phe Ala Thr Arg Leu Tyr His 
1               5                   10                  15      


Ala Pro Leu Ser Glu His Gly Pro Ala Leu Asp Pro Ala Glu Phe Ala 
            20                  25                  30          


Ala Ser Cys Tyr Ser Ile Ala Glu Asp Asp Asp Ala Gly Gln Glu Trp 
        35                  40                  45              


Cys Glu Arg Glu Gly Tyr Pro Gly Tyr Thr Ser Tyr Ala Ser Leu Thr 
    50                  55                  60                  


Asp Leu Pro Trp Arg Phe Pro Ile Phe Ala Asp Leu Val Lys Ser Leu 
65                  70                  75                  80  


Asp Ala His Val Ala Ala Phe Ala Glu Asp Leu Glu Phe Glu Leu Asp 
                85                  90                  95      


Gly Lys Ala Leu Arg Leu Glu Asp Ile Trp Ile Asn Ile Leu Pro Glu 
            100                 105                 110         


Gly Gly Val His Gly Ser His Ile His Pro His Ser Val Ile Ser Gly 
        115                 120                 125             


Thr Thr Tyr Val Ala Met Pro Glu Gly Thr Ser Ala Leu Lys Leu Glu 
    130                 135                 140                 


Asp Pro Arg Leu Pro Phe Met Met Ala Ala Pro Thr Arg Arg Lys Gly 
145                 150                 155                 160 


Ala Arg Glu Glu Leu Arg Thr Phe Arg Ser Val Ala Pro Lys Val Gly 
                165                 170                 175     


Asp Val Leu Leu Trp Glu Ser Trp Leu Arg His Glu Val Pro Met Asn 
            180                 185                 190         


Met Ala Glu Glu Asp Arg Ile Ser Val Ser Phe Asn Tyr Ala Trp Gly 
        195                 200                 205             


Glu Gly His His His His His His 
    210                 215     


<210> 40
<211> 394
<212> PRT
<213> Ruegeria pomeroyi

<400> 40
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Pro Thr Glu Ile Lys Pro Glu Asp Asp Ile 
            20                  25                  30          


Leu Gly Arg Ala Arg Val Arg Asp Thr Pro Glu Leu Glu Ala Tyr Tyr 
        35                  40                  45              


Asp Asp Leu Ala Lys Ile Glu Thr Gly Ala Leu Trp Thr Val Ala Asn 
    50                  55                  60                  


Asp Ile Glu Pro Trp Glu Pro Thr Pro Lys Ser Ala Pro Val His Trp 
65                  70                  75                  80  


Lys Trp Ser Asp Leu Arg Arg Glu Val Leu Arg Ala Ile Asp Leu Val 
                85                  90                  95      


Arg Pro Glu Asp Ala Gly Arg Arg Val Val Tyr Leu Arg Asn Pro Gln 
            100                 105                 110         


Arg Lys Asp Val Ser Ala Ala Cys Gly Trp Leu Phe Ser Gly Ile Gln 
        115                 120                 125             


Thr Met Lys Ala Gly Glu Arg Ala Gly Ala His Arg His Ala Ala Ser 
    130                 135                 140                 


Ala Leu Arg Phe Ile Met Glu Gly Ser Gly Ala Tyr Thr Ile Val Asp 
145                 150                 155                 160 


Gly His Lys Val Glu Leu Gly Ala Asn Asp Phe Val Leu Thr Pro Asn 
                165                 170                 175     


Gly Thr Trp His Glu His Gly Ile Leu Glu Ser Gly Thr Glu Cys Ile 
            180                 185                 190         


Trp Gln Asp Gly Leu Asp Ile Pro Leu Thr Asn Cys Leu Glu Ala Asn 
        195                 200                 205             


Phe Tyr Glu Val His Pro Asn Asp Tyr Gln Thr Thr Asp Ile Pro Leu 
    210                 215                 220                 


Asn Asp Ser Pro Leu Thr Tyr Gly Gly Pro Ala Leu Leu Pro Gln Leu 
225                 230                 235                 240 


Asp Lys Trp Asp Lys Pro Tyr Ser Pro Leu Leu Lys Tyr Ser Trp Glu 
                245                 250                 255     


Pro Thr Tyr Glu Ala Leu Leu Asn Tyr Ala Lys Ala Ser Asp Gly Ser 
            260                 265                 270         


Pro Tyr Asp Gly Leu Ile Leu Arg Tyr Thr Asn Pro Gln Thr Gly Gly 
        275                 280                 285             


His Pro Met Leu Thr Met Gly Ala Ser Met Gln Met Leu Arg Pro Gly 
    290                 295                 300                 


Glu His Thr Lys Ala His Arg His Thr Gly Asn Val Ile Tyr Asn Val 
305                 310                 315                 320 


Ala Lys Gly Gln Gly Tyr Ser Ile Val Gly Gly Lys Arg Phe Asp Trp 
                325                 330                 335     


Ser Glu His Asp Ile Phe Cys Val Pro Ala Trp Thr Trp His Glu His 
            340                 345                 350         


Cys Asn Thr Gln Glu Arg Asp Asp Ala Cys Leu Phe Ser Phe Asn Asp 
        355                 360                 365             


Phe Pro Val Met Glu Lys Leu Gly Phe Trp Ala Glu Gln Ala Leu Glu 
    370                 375                 380                 


Asp Asn Gly Gly His Gln Ile Val Ala Asp 
385                 390                 


